Ohmori Yumi, Ito Hiroto, Morita Akemi, Deura Kijo, Miyachi Motohiko
Department of Social Psychiatry, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan. Email:
Department of Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo, Japan.
Asia Pac J Clin Nutr. 2017 Jan;26(1):130-140. doi: 10.6133/apjcn.112015.01.
The purpose of the present study was to determine whether depression was associated with metabolic syndrome and unhealthy behaviours in community residents.
Using the 2009-2010 baseline data of the Saku Cohort Study, 1,225 men and women who participated in a community health screening were included in the cross-sectional analyses. Depression was assessed using the Zung Self-Rating Depression Scale. Consistent with the Japanese Society of Internal Medicine's definition, we defined metabolic syndrome as abdominal obesity plus two or more of the following: high blood pressure, hyperglycaemia, and dyslipidaemia. We defined 'pre- and metabolic syndrome' as the presence of one or more of the three criteria in addition to abdominal obesity.
There was no significant association between depression and metabolic syndrome. In women, the prevalence of pre- and metabolic syndrome was significantly higher in the depression group than that in the non-depression group (17.5% vs 9.5%, p=0.046), whereas no such significant association was observed in men. Logistic regression analysis showed that depression was associated with unhealthy behavioural factors differently in men and women.
This study revealed that depression was associated with several unhealthy behavioural factors in both men and women, but depression was associated with pre- and metabolic syndrome only in women. These findings suggest that depression may be a warning sign of metabolic syndrome in women with unhealthy behavioural factors. Psychological factors should be considered in addition to the assessment of physical status.
本研究旨在确定社区居民中抑郁症是否与代谢综合征及不健康行为相关。
采用佐久队列研究2009 - 2010年的基线数据,1225名参与社区健康筛查的男性和女性纳入横断面分析。使用zung自评抑郁量表评估抑郁情况。按照日本内科医学会的定义,我们将代谢综合征定义为腹型肥胖加以下两项或更多项:高血压、高血糖和血脂异常。我们将“代谢综合征前期和代谢综合征”定义为除腹型肥胖外存在三项标准中的一项或多项。
抑郁症与代谢综合征之间无显著关联。在女性中,抑郁症组的代谢综合征前期和代谢综合征患病率显著高于非抑郁症组(17.5%对9.5%,p = 0.046),而在男性中未观察到这种显著关联。逻辑回归分析表明,抑郁症与不健康行为因素在男性和女性中的关联不同。
本研究表明,抑郁症在男性和女性中均与多种不健康行为因素相关,但抑郁症仅在女性中与代谢综合征前期和代谢综合征相关。这些发现表明,抑郁症可能是具有不健康行为因素女性代谢综合征的一个警示信号。除了评估身体状况外,还应考虑心理因素。