Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.
Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Blood. 2017 Feb 23;129(8):934-939. doi: 10.1182/blood-2016-09-728006. Epub 2017 Jan 3.
We performed a meta-analysis to evaluate the risk of venous thromboembolism (VTE) in pregnant women with essential thrombocythemia. Twenty-one trials and 756 pregnancies met inclusion criteria. The absolute VTE risk in the antepartum period is not above a threshold where low-molecular-weight heparin (LMWH) prophylaxis is clearly indicated or below a threshold where LMWH should be withheld (2.5%; 95% CI, 1.3-4.3). Postpartum, the absolute VTE risk is above a threshold where postpartum LMWH prophylaxis should be considered (4.4%; 95% CI, 1.2-9.5).
我们进行了一项荟萃分析，以评估原发性血小板增多症孕妇发生静脉血栓栓塞（VTE）的风险。21 项试验和 756 例妊娠符合纳入标准。在产前期间，VTE 的绝对风险未超过低分子肝素（LMWH）预防治疗明确指征的阈值，也未低于 LMWH 应被禁忌的阈值（2.5%；95%CI，1.3-4.3）。产后，VTE 的绝对风险超过了产后 LMWH 预防治疗应被考虑的阈值（4.4%；95%CI，1.2-9.5）。
