Mshana Happyness J, Baraka Vito, Misinzo Gerald, Makunde Williams H
National Institute for Medical Research, Tanga Research Centre, P.O. Box 5004, Tanga, Tanzania; Sokoine University of Agriculture, Morogoro, Tanzania.
National Institute for Medical Research, Tanga Research Centre, P.O. Box 5004, Tanga, Tanzania; Global Health Institute, University of Antwerp, Antwerp, Belgium.
J Trop Med. 2016;2016:7408187. doi: 10.1155/2016/7408187. Epub 2016 Dec 6.
. Tanzania started a countrywide lymphatic filariasis elimination programme in 2000 adopting the mass drug administration (MDA) strategy. The drug used for the programme was the combination of ivermectin and albendazole. However, there is limited information on the current epidemiological trend of the infections, where MDA implementation is ongoing. The present study aimed at assessing the current status of Bancroftian filariasis infection rate and morbidity where MDA has been distributed and administered for over eight rounds. . The study was a cross-sectional descriptive study involving 272 individuals (>18 years) from endemic communities in Tanga region where MDA has been implemented. Clinical, sociodemographic, and circulating filarial antigen (CFA) test was undertaken using immune chromatographic card test according to the manufacturer's instructions. . A total of 472 individuals were screened: 307/472 (65.1%) were males while 165/472 (34.9%) were females. The overall prevalence of CFA was 5.51%, that of hydrocoele was 73.2%, and that of lymphoedema was 16.0%. The prevalence of hydrocoele combined with lymphoedema was 5.5%. . Our findings demonstrate a considerable reduction in filarial infection. However, there is clear evidence of ongoing transmission despite the 8 rounds of MDA. It is unlikely that the annual MDA would interrupt filarial transmission; therefore, additional strategies are needed to accelerate lymphatic filariasis control and elimination.
坦桑尼亚于2000年启动了一项全国性的淋巴丝虫病消除计划，采用了群体药物给药（MDA）策略。该计划使用的药物是伊维菌素和阿苯达唑的组合。然而，关于正在实施MDA地区当前感染的流行病学趋势的信息有限。本研究旨在评估在已进行了八轮以上MDA分发和给药地区班氏丝虫病的感染率和发病率现状。 该研究是一项横断面描述性研究，涉及坦噶地区实施了MDA的流行社区中的272名个体（>18岁）。根据制造商的说明，使用免疫层析卡试验进行临床、社会人口统计学和循环丝虫抗原（CFA）检测。 总共筛查了472人：472人中307人（65.1%）为男性，165人（34.9%）为女性。CFA的总体患病率为5.51%，鞘膜积液的患病率为73.2%，淋巴水肿的患病率为16.0%。鞘膜积液合并淋巴水肿的患病率为5.5%。 我们的研究结果表明丝虫感染有显著减少。然而，尽管进行了8轮MDA，仍有明显的传播证据。每年的MDA不太可能中断丝虫传播；因此，需要额外的策略来加速淋巴丝虫病的控制和消除。
