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因皮样窦导致的继发性脊髓炎致使一名既往神经功能正常的儿童截瘫

Secondary Myelitis in Dermal Sinus Causing Paraplegia in a Child with Previously Normal Neurological Function.

作者信息

Rashid Sakina, Kinabo Grace, Kellogg Marissa, Howlett William P, Dekker Marieke C J

机构信息

Department of Pediatrics, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.

Stanford University, Palo Alto, CA, USA.

出版信息

Case Rep Neurol Med. 2016;2016:8918954. doi: 10.1155/2016/8918954. Epub 2016 Dec 6.

Abstract

Neural tube defects result from failure of neural tube fusion during early embryogenesis, the fourth week after conception. The spectrum of severity is not uniform across the various forms of this congenital anomaly as certain presentations are not compatible with extrauterine life (anencephaly) while, on the other hand, other defects may remain undiagnosed as they are entirely asymptomatic (occult spina bifida). We report a child with previously normal neurological development, a devastating clinical course following superinfection of a subtle spina bifida defect which resulted in a flaccid paralysis below the level of the lesion and permanent neurological deficits following resolution of the acute infection and a back closure surgery.

摘要

神经管缺陷是由于在胚胎发育早期(受孕后第四周)神经管融合失败所致。这种先天性异常的各种形式的严重程度并不一致,某些表现与宫外生活不兼容(无脑儿),而另一方面,其他缺陷可能因完全无症状而未被诊断出来(隐性脊柱裂)。我们报告了一名儿童,其神经发育先前正常,在轻微脊柱裂缺陷发生重复感染后出现了灾难性的临床病程,导致病变水平以下出现弛缓性麻痹,在急性感染消退和进行背部闭合手术后遗留永久性神经功能缺损。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c8/5168452/f4bc26f810e9/CRINM2016-8918954.001.jpg

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