丘脑底核的深部脑刺激频率影响帕金森病的音素流畅性和动作流畅性。
Deep Brain Stimulation Frequency of the Subthalamic Nucleus Affects Phonemic and Action Fluency in Parkinson's Disease.
作者信息
Fagundes Valéria de Carvalho, Rieder Carlos R M, da Cruz Aline Nunes, Beber Bárbara Costa, Portuguez Mirna Wetters
机构信息
Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil; Brain Institute of Rio Grande do Sul (InsCer), Porto Alegre, RS, Brazil; Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.
Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil; Federal University of Health Sciences from Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil.
出版信息
Parkinsons Dis. 2016;2016:6760243. doi: 10.1155/2016/6760243. Epub 2016 Dec 5.
Deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) has been linked to a decline in verbal fluency. The decline can be attributed to surgical effects, but the relative contributions of the stimulation parameters are not well understood. This study aimed to investigate the impact of the frequency of STN-DBS on the performance of verbal fluency tasks in patients with PD. Twenty individuals with PD who received bilateral STN-DBS were evaluated. Their performances of verbal fluency tasks (semantic, phonemic, action, and unconstrained fluencies) upon receiving low-frequency (60 Hz) and high-frequency (130 Hz) STN-DBS were assessed. The performances of phonemic and action fluencies were significantly different between low- and high-frequency STN-DBS. Patients showed a decrease in these verbal fluencies for high-frequency STN-DBS. Low-frequency STN-DBS may be less harmful to the verbal fluency of PD patients.
帕金森病（PD）患者丘脑底核深部脑刺激（STN-DBS）与言语流畅性下降有关。这种下降可归因于手术效果，但刺激参数的相对作用尚不清楚。本研究旨在探讨STN-DBS频率对PD患者言语流畅性任务表现的影响。对20例接受双侧STN-DBS的PD患者进行了评估。评估了他们在接受低频（60Hz）和高频（130Hz）STN-DBS时言语流畅性任务（语义、音素、动作和无限制流畅性）的表现。低频和高频STN-DBS之间，音素和动作流畅性的表现存在显著差异。高频STN-DBS时患者这些言语流畅性下降。低频STN-DBS可能对PD患者的言语流畅性危害较小。
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