Sutrisna Em
Senior Lecturer, Department of Pharmacology, Faculty of Medicine, Universitas Muhammadiyah Surakarta , Indonesia .
J Clin Diagn Res. 2016 Nov;10(11):FE01-FE03. doi: 10.7860/JCDR/2016/21067.8914. Epub 2016 Nov 1.
Theophylline is a medicine with narrow therapeutic index. This implies that a small change in dosage would cause side effects. Theophylline is metabolized by CYP1A2 and CYP2E1. The aim of this review is to know the impact of CYP1A2 and CYP2E1 genes polymorphism on theophylline response. The review was done by searching literature in Pubmed and Science Direct databases with keywords 'polymorphism', 'pharmacogenetic', 'CYP1A2', 'CYP2E1' and 'theophylline'. There were 5 research articles from Pubmed and 65 articles (21 research articles, 23 review articles and 21 book chapters) from Science Direct. The exclusion criteria were - articles discussing about polymorphism but not CYP1A2 or CYP2E1, the ones with a mention of theophylline but not about its metabolism, articles on CYP1A2 and/or 2E1 polymorphism but not on the effect on theophylline. Thus, 33 articles were reviewed due to their suitability. The review discusses the influence of polymorphism of CYP1A2 and CYP2E1 genes on theophylline response.
茶碱是一种治疗指数狭窄的药物。这意味着剂量的微小变化就会引起副作用。茶碱由细胞色素P450 1A2（CYP1A2）和细胞色素P450 2E1（CYP2E1）代谢。本综述的目的是了解CYP1A2和CYP2E1基因多态性对茶碱反应的影响。该综述通过在PubMed和科学Direct数据库中搜索关键词“多态性”“药物遗传学”“CYP1A2”“CYP2E1”和“茶碱”来完成。来自PubMed的有5篇研究文章，来自科学Direct的有65篇文章（21篇研究文章、23篇综述文章和21篇书籍章节）。排除标准为——讨论多态性但不是关于CYP1A2或CYP2E1的文章，提及茶碱但未涉及其代谢的文章，关于CYP1A2和/或2E1多态性但未涉及对茶碱影响的文章。因此，由于其适用性，共审查了33篇文章。该综述讨论了CYP1A2和CYP2E1基因多态性对茶碱反应的影响。
