Ledda A, Belcaro G, Dugall M, Feragalli B, Riva A, Togni S, Giacomelli L
Department of Medical, Oral and Biotechnological Sciences (SMO), Irvine3 Laboratories, Chieti-Pescara University, Italy.
Eur Rev Med Pharmacol Sci. 2016 Dec;20(24):5205-5209.
Recently, cranberry extracts have been tested as a nutritional supplementation in the prevention of lower urinary tract symptoms (LUTS) as well as recurrent urinary tract infections (UTIs) in subjects at risk, with mixed results. However, evidence of efficacy should be considered only for well-characterized and standardized products in a more selected study population. Moreover, the efficacy of these interventions in elderly must be further investigated. The aim of this pilot, registry study was to evaluate the prophylactic effects of an oral supplementation containing a highly concentrated and standardized cranberry extract reproducing the natural total profile of cranberry fruits, in elderly men with benign prostatic hyperplasia (BPH), suffering from recurrent UTIs, over a 2-months follow-up.
43 men (age > 65 years) enrolled in this study freely decided to receive either a standard management (SM) only (n = 21) or SM associated with an oral supplementation (n = 23). Supplementation consisted in a daily administration of one capsule containing cranberry extract (Anthocran®) for 60 consecutive days. The clinical effectiveness in the prevention of UTIs was determined by the number of UTIs in the two months before the inclusion in the registry and during the supplementation period, and the number of symptom-free subjects during the registry period. Safety considerations were also performed.
In the supplemented group, the mean number of UTI episodes reported during the registry (0.8 ± 0.5) significantly decreased compared with inclusion time (3.2 ± 1.3), p-value = 0.0001. No significant changes were observed in control, SM-only group. Importantly, the cranberry oral supplementation was superior over SM at reducing the mean number of UTIs (p-value = 0.0062).
These results suggest that cranberry supplementation could be an effective and safe approach, within an SM program, for the prevention of recurrent UTIs in elderly men suffering from BPH avoiding some antibiotic treatments.
最近，蔓越莓提取物已被作为一种营养补充剂进行测试，用于预防有风险人群的下尿路症状（LUTS）以及复发性尿路感染（UTI），但结果不一。然而，只有在更具选择性的研究人群中，针对特征明确且标准化的产品，其疗效证据才应被考虑。此外，这些干预措施在老年人中的疗效必须进一步研究。这项初步的登记研究旨在评估一种口服补充剂的预防效果，该补充剂含有高度浓缩和标准化的蔓越莓提取物，能再现蔓越莓果实的天然整体成分，用于患有良性前列腺增生（BPH）且复发性UTI的老年男性，随访期为2个月。
43名年龄大于65岁的男性自愿参与本研究，他们自主决定要么仅接受标准管理（SM）（n = 21），要么接受与口服补充剂联合的SM（n = 23）。补充剂为连续60天每日服用一粒含蔓越莓提取物（Anthocran®）的胶囊。预防UTI的临床有效性通过纳入登记前两个月和补充期内的UTI次数，以及登记期内无症状受试者的数量来确定。同时也进行了安全性考量。
在补充剂组中，登记期间报告的UTI发作平均次数（0.8±0.5）与纳入时（3.2±1.3）相比显著减少，p值 = 0.0001。在仅接受SM的对照组中未观察到显著变化。重要的是，蔓越莓口服补充剂在降低UTI平均次数方面优于SM（p值 = 0.0062）。
这些结果表明，在SM方案中，蔓越莓补充剂可能是一种有效且安全的方法，可用于预防患有BPH的老年男性复发性UTI，避免一些抗生素治疗。
