Institute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, and Humboldt-Universität zu Berlin, Berlin, Germany.
Department of Internal and Integrative Medicine, Immanuel Hospital Berlin, Berlin, Germany.
J Integr Complement Med. 2022 May;28(5):399-406. doi: 10.1089/jicm.2021.0300. Epub 2022 Mar 14.
Cranberries () are traditionally used in prevention of urinary tract infections (UTIs). The authors' aim was to evaluate effects of a supplement containing cranberry extract, pumpkin seed extract, vitamin C, and vitamin B on recurrent uncomplicated UTIs in women and their intestinal microbiota. A prospective, uncontrolled exploratory study was conducted in women with recurrent uncomplicated UTIs. The primary exploratory outcome was the number of UTIs in a 6-month prospective observation period compared with a 6-month retrospective period. Further outcomes included number of antibiotics, quality of life (SF-36), intestinal microbiota (assessed by 16S rRNA amplicon sequencing), and evaluation questions. Parameters were assessed at baseline and after 1, 2, and 7 months (start of intake of cranberry supplement after 1 month for 6 months). -Values were calculated with the pairwise Wilcoxon signed-rank test for α diversity and permutational multivariate analysis of variance. Twenty-three women (aged 52.7 ± 12.4 years) were included in the study. Participants reported 2.2 ± 0.8 UTIs (at baseline) in the previous 6 months. After 6 months of cranberry intake, participants reported a significant decrease to 0.5 ± 0.9 UTIs ( < 0.001). Number of antibiotic therapies was also significantly ( < 0.001) reduced by 68% during 6 months of cranberry intake (0.14 ± 0.35) when compared with 6 months retrospectively (1.14 ± 0.71). The SF-36 physical component score increased from 44.9 ± 5.5 at baseline to 45.7 ± 4.6 at 7 months ( = 0.16). The SF-36 mental component score decreased slightly from the baseline value of 46.5 ± 6.5 to 46.2 ± 6.4 at 7 months ( = 0.74). No significant intragroup mean changes at genus, family, or species level for α and β diversity within the intestinal microbiota were found. In the evaluation questions, participants rated the cranberry extract positively and considered it beneficial. The supplement intake was safe. This study shows that women with recurrent uncomplicated UTIs benefit from cranberry intake. Future larger clinical studies with further investigation of the mechanisms of action are required to determine the effects of cranberries on participants with uncomplicated UTIs.
蔓越莓（）传统上用于预防尿路感染（UTI）。作者的目的是评估含有蔓越莓提取物、南瓜籽提取物、维生素 C 和维生素 B 的补充剂对女性复发性单纯性尿路感染及其肠道微生物群的影响。一项前瞻性、非对照性探索性研究在患有复发性单纯性尿路感染的女性中进行。主要的探索性结果是在 6 个月的前瞻性观察期与 6 个月的回顾性期相比，尿路感染的数量。进一步的结果包括抗生素的数量、生活质量（SF-36）、肠道微生物群（通过 16S rRNA 扩增子测序评估）和评估问题。在基线和 1、2 和 7 个月（在开始摄入蔓越莓补充剂 1 个月后 6 个月）时评估参数。使用基于配对的 Wilcoxon 符号秩检验计算 α 多样性和置换多元方差分析的 值。23 名女性（年龄 52.7±12.4 岁）纳入研究。参与者报告在过去 6 个月中有 2.2±0.8 次 UTI（基线时）。在摄入蔓越莓 6 个月后，参与者报告尿路感染显著减少至 0.5±0.9 次（<0.001）。在摄入蔓越莓的 6 个月期间，抗生素治疗的数量也显著减少（<0.001），减少了 68%（0.14±0.35），而回顾性的 6 个月为 1.14±0.71。SF-36 生理成分评分从基线时的 44.9±5.5 增加到 7 个月时的 45.7±4.6（=0.16）。SF-36 心理成分评分从基线时的 46.5±6.5 略有下降至 7 个月时的 46.2±6.4（=0.74）。在肠道微生物群的 α 和 β 多样性的属、科和种水平上，未发现组内平均变化有统计学意义。在评估问题中，参与者对蔓越莓提取物给予了积极评价，并认为其有益。补充剂的摄入是安全的。这项研究表明，患有复发性单纯性尿路感染的女性从蔓越莓摄入中受益。需要进一步研究作用机制的更大规模的临床研究，以确定蔓越莓对单纯性尿路感染参与者的影响。
