Inada H, Endoh M, Katayama K, Kakemi M, Koizumi T
Chem Pharm Bull (Tokyo). 1989 Jul;37(7):1870-3. doi: 10.1248/cpb.37.1870.
Permeation of sulfisoxazole (SIX) across the excised rat skin were studied using two chamber cell with four electrodes, under three successive experimental conditions: without current for 3 h (treatment I), with current for 4 h (treatment II) and without current for 3 h (treatment III). Transport of SIX was significantly increased by iontophoresis. The enhancement ratio of SIX flux were reasonably predicted by Goldman's equation. There was no significant difference (p less than 0.05) between the flux in treatment I and treatment III. On the basis of the flux reversibility, it was concluded that skin alteration did not occur when the applied electric potential was below 5.025 V. Although a prominent current-induced volume flow (from the anodal side to the cathodal side) was observed during current exposure, SIX flux was not influenced by the volume flow. The flux enhancement of SIX was mainly dependent on transdermal potential difference.
使用带有四个电极的双室细胞，在三种连续的实验条件下研究了磺胺异恶唑（SIX）透过切除的大鼠皮肤的情况：无电流作用3小时（处理I）、有电流作用4小时（处理II）和无电流作用3小时（处理III）。离子导入显著增加了SIX的转运。SIX通量的增强率可通过戈德曼方程合理预测。处理I和处理III中的通量之间无显著差异（p小于0.05）。基于通量可逆性，得出结论：当施加的电势低于5.025 V时，皮肤未发生改变。尽管在电流作用期间观察到明显的电流诱导体积流（从阳极侧向阴极侧），但SIX通量不受体积流影响。SIX通量的增强主要取决于透皮电位差。
