脊柱关节炎中关节外症状与特定血清细胞因子及疾病活动的关系
Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis.
作者信息
Przepiera-Będzak Hanna, Fischer Katarzyna, Brzosko Marek
机构信息
Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Independent Laboratory of Rheumatic Diagnostics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
出版信息
Mediators Inflamm. 2016;2016:7617954. doi: 10.1155/2016/7617954. Epub 2016 Dec 7.
In this study, we assessed the extra-articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis (SpA). We studied 287 SpA patients: 131 had AS, 110 had PsA, and 46 had SAPHO. We assessed extra-articular symptoms in all cases. In 191 SpA patients, we measured serum interleukin-6 (IL-6), interleukin-18 (IL-18), interleukin-23 (IL-23), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). Patients with acute anterior uveitis (AAU) had higher VAS ( = 0.0008), BADSDAI ( = 0.0001), ASDAS-ESR ( = 0.04), CRP ( = 0.006), IL-6 ( = 0.02), and IL-18 ( = 0.03) levels. Patients with inflammatory bowel disease (IBD) had higher VAS ( = 0.03), CRP ( = 0.0009), and IL-6 ( = 0.0003) levels. Patients with skin psoriasis had lower VAS ( = 0.001) and BASDAI ( = 0.00007) levels. Patients with psoriatic onycholysis had lower VAS ( = 0.006), BASDAI ( = 0.00001), and CRP ( = 0.02) and higher IL-23 ( = 0.04) levels. Patients with PPP had lower BASDAI ( = 0.04) and higher ET-1 ( = 0.001) levels. SpA patients with increased serum IL-18 and decreased serum ET-1 had an increased risk of extra-articular symptoms. In SpA patients, increased disease activity was associated with an increased risk of AAU and IBD and a decreased risk of skin psoriasis, psoriatic onycholysis, and PPP.
在本研究中，我们评估了脊柱关节炎（SpA）患者关节外症状与选定血清细胞因子及疾病活动度之间的关系。我们研究了287例SpA患者：131例为强直性脊柱炎（AS），110例为银屑病关节炎（PsA），46例为滑膜炎、痤疮、脓疱病、骨肥厚、骨炎综合征（SAPHO）。我们评估了所有病例的关节外症状。在191例SpA患者中，我们检测了血清白细胞介素-6（IL-6）、白细胞介素-18（IL-18）、白细胞介素-23（IL-23）、内皮素-1（ET-1）、血管内皮生长因子（VEGF）和表皮生长因子（EGF）。急性前葡萄膜炎（AAU）患者的视觉模拟评分（VAS，P = 0.0008）、巴斯强直性脊柱炎疾病活动指数（BADSDAI，P = 0.0001）、强直性脊柱炎疾病活动评分-红细胞沉降率（ASDAS-ESR，P = 0.04）、C反应蛋白（CRP，P = 0.006）、IL-6（P = 0.02）和IL-18（P = 0.03）水平较高。炎症性肠病（IBD）患者的VAS（P = 0.03）、CRP（P = 0.0009）和IL-6（P = 0.0003）水平较高。皮肤银屑病患者的VAS（P = 0.001）和巴斯强直性脊柱炎疾病活动指数（BASDAI，P = 0.00007）水平较低。银屑病甲剥离患者的VAS（P = 0.006）、BASDAI（P = 0.00001）和CRP（P = 0.02）水平较低，而IL-23（P = 0.04）水平较高。掌跖脓疱病（PPP）患者的BASDAI（P = 0.04）水平较低，ET-1（P = 0.001）水平较高。血清IL-18升高且血清ET-1降低的SpA患者出现关节外症状的风险增加。在SpA患者中，疾病活动度增加与AAU和IBD风险增加以及皮肤银屑病、银屑病甲剥离和PPP风险降低相关。
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