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巨大哑铃型颈椎神经鞘瘤治疗中的手术细微差别:1例具有挑战性病例的描述及文献综述

Surgical nuances on the treatment of giant dumbbell cervical spine schwannomas: description of a challenging case and review of the literature.

作者信息

Iacopino Domenico Gerardo, Giugno Antonella, Gulì Carlo, Basile Luigi, Graziano Francesca, Maugeri Rosario

机构信息

Department of Experimental Biomedicine and Clinical Neurosciences (Bionec), School of Medicine, Neurosurgical Clinic, University of Palermo , Palermo, Italy.

出版信息

Spinal Cord Ser Cases. 2016 Apr 7;2:15042. doi: 10.1038/scsandc.2015.42. eCollection 2016.

Abstract

We report a case of a giant intra and extradural cervical schwannoma in a patient affected by a severe myelo-radiculopathy. Clinical features, diagnosis and the issues concerning the surgical management of this benign tumor are discussed. We also review similar cases previously reported in the literature. A 50-year old caucasian woman was complaining of a 1 year of neck pain and worsening motor impairment in all four limbs causing the inability to walk. Neuroradiological assessment revealed a suspected schwannoma involving the nerve roots from C3 to C5, compressing and deviating the spinal cord. The vertebral artery was also encased within the lesion, but still patent. A posterior cervical laminectomy with a microsurgical extradural resection of the lesion was performed. Moreover, an accurate dissection of the lesion from the vertebral artery and the resection of the intraspinal component was achieved. Vertebral fixation with screws on the lateral masses of C3, C5 and C6 and a hook on C1 was performed. The procedure was secured using electroneurophysiological monitoring. A progressive improvement of the motor functions was achieved. A cervical post-contrast MRI revealed optimal medullary decompression and a gross-total resection of the lesion. Schwannomas are benign, slowly growing lesions which may cause serious neurological deficit. Early diagnosis is necessary and it maybe aided by imaging studies such as MRI or CT. The accepted treatment for these tumors is surgical resection and, when indicated, vertebral fixation.

摘要

我们报告了一例患有严重脊髓神经根病的患者,其患有巨大的颈椎硬膜内及硬膜外神经鞘瘤。讨论了该良性肿瘤的临床特征、诊断及手术治疗相关问题。我们还回顾了文献中先前报道的类似病例。一名50岁的白人女性主诉颈部疼痛1年,四肢运动功能逐渐恶化,导致无法行走。神经放射学评估显示疑似神经鞘瘤累及C3至C5神经根,压迫并使脊髓移位。椎动脉也被包绕在病变内,但仍通畅。进行了颈椎后路椎板切除术及病变的显微硬膜外切除术。此外,还实现了从椎动脉精确分离病变及切除脊髓内部分。在C3、C5和C6侧块上用螺钉进行椎体固定,并在C1上使用钩进行固定。手术过程中使用神经电生理监测确保安全。运动功能逐渐改善。颈椎增强MRI显示脊髓减压效果良好,病变实现了全切除。神经鞘瘤是良性、生长缓慢的病变,可能导致严重的神经功能缺损。早期诊断很有必要,MRI或CT等影像学检查可能有助于诊断。这些肿瘤公认的治疗方法是手术切除,必要时进行椎体固定。

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