Peereboom-Wynia J D, Koerten H K, Van Joost T, Stolz E
Clin Exp Dermatol. 1989 Jan;14(1):47-50. doi: 10.1111/j.1365-2230.1989.tb00882.x.
A scanning electron microscope was used to compare the distal ends of exclamation mark hairs from alopecia areata patients with the fracture surface of normal hair fibres, mechanically broken by traction. The exclamation mark hairs shows minimal damage to the cuticular cell pattern of the hair shaft. Where the cuticle was absent, cortex and medulla showed low-density features fanning out into a fringe-like structure at the distal ends. The fracture surfaces of normal hair fibres, mechanically broken by traction showed a markedly abnormal cuticular scale pattern, whereas the features of cortical and medullary tissue were normal. These morphological differences between the fracture surface of exclamation mark hairs and normal hair fibres, mechanically broken by traction, may enhance our understanding of the pathogenesis of alopecia areata.
使用扫描电子显微镜比较斑秃患者惊叹号样毛发的远端与正常毛发纤维经牵引机械性折断后的断裂面。惊叹号样毛发对毛干角质形成细胞模式的损伤极小。在无角质层的部位，皮质和髓质呈现低密度特征，并在远端呈扇形展开形成边缘样结构。经牵引机械性折断的正常毛发纤维的断裂面显示出明显异常的角质层鳞片模式，而皮质和髓质组织的特征正常。惊叹号样毛发与经牵引机械性折断的正常毛发纤维断裂面之间的这些形态学差异，可能会增进我们对斑秃发病机制的理解。
