具有超高碘含量的纳米聚合物囊泡用于体内高性能 X 射线计算机断层成像。
Nanopolymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo.
机构信息
Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P.R. China.
Department of Biomaterials Science and Technology, MIRA Institute for Biological Technology and Technical Medicine, University of Twente, PO Box 217, 7500AE, Enschede, The Netherlands.
出版信息
Adv Mater. 2017 Mar;29(10). doi: 10.1002/adma.201603997. Epub 2017 Jan 5.
Biocompatible and biodegradable nanopolymersomes with an unprecedented iodine content, low viscosity, and iso-osmolality achieve significantly enhanced CT imaging of blood pool and the reticuloendothelial system. Moreover, in subcutaneous and orthotopic tumor models in mice, they show enhanced in vivo imaging when compared to iohexol, a clinically used small-molecule contrast agent.
具有空前碘含量、低粘度和等渗性的生物相容和可生物降解的纳米聚合物囊泡实现了血池和网状内皮系统的显著增强 CT 成像。此外，与临床使用的小分子造影剂碘海醇相比，在小鼠皮下和原位肿瘤模型中，它们显示出增强的体内成像。
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