Jiménez Karen M, Pereira-Morales Angela J, Forero Diego A
a Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine , Universidad Antonio Nariño , Bogotá , Colombia.
Chronobiol Int. 2017;34(2):280-286. doi: 10.1080/07420528.2016.1268149. Epub 2017 Jan 5.
A polymorphism in the PER3 (period circadian clock 3) gene has been associated with neuropsychiatric disorders and endophenotypes. We evaluated the possible association of personality domains with the PER3 polymorphism in a sample of healthy subjects: 271 individuals were evaluated with the Big Five Inventory and genotyped for the PER3 Variable Number Tandem Repeat (VNTR) polymorphism. We found a significant association between the PER3 polymorphism and the extraversion personality trait (p = 0.0093). The 5/5 genotype carriers showed higher scores for extraversion. This is the first time that a significant association between the PER3 VNTR polymorphism and extraversion is reported.
PER3（周期昼夜节律时钟3）基因的一种多态性与神经精神疾病及内表型有关。我们在一组健康受试者样本中评估了人格维度与PER3多态性之间的可能关联：271名个体接受了大五人格量表评估，并对PER3可变数目串联重复序列（VNTR）多态性进行了基因分型。我们发现PER3多态性与外向型人格特质之间存在显著关联（p = 0.0093）。5/5基因型携带者在外向性方面得分更高。这是首次报道PER3 VNTR多态性与外向性之间存在显著关联。
