通过Suzuki-Miyaura 偶联/Petasis 缩合序列合成 1-氨基-1H-茚。
Synthesis of 1-Amino-1H-Indenes via a Sequential Suzuki-Miyaura Coupling/Petasis Condensation Sequence.
机构信息
Organic and Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology , Tarnaka, Hyderabad 500 006, India.
Institut des Sciences Chimiques de Rennes, UMR 6226, CNRS-Université de Rennes 1 , 263, Avenue du Général Leclerc, Campus de Beaulieu, 35042 Rennes Cedex, France.
出版信息
J Org Chem. 2017 Feb 3;82(3):1803-1811. doi: 10.1021/acs.joc.6b02549. Epub 2017 Jan 23.
An efficient and straightforward synthesis of 1-amino-1H-indenes is reported from 1,2-bis(boronates) via a sequential Suzuki-Miyaura coupling/Petasis cyclization reaction. Starting from the same monoboronic ester intermediates, an intermolecular version of this approach also afforded (Z)-α,β-unsaturated amino esters in moderate to good yields.
本文报道了一种从 1,2-双(硼酸酯)通过顺序 Suzuki-Miyaura 偶联/Petasis 环化反应高效、直接合成 1-氨基-1H-茚的方法。从相同的单硼酸酯中间体出发，这种方法的分子间版本也以中等至良好的收率得到(Z)-α,β-不饱和氨基酯。
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