基于体素的皮层厚度和形态测量分析显示多动症儿童的神经改变。
Neural alterations in ADHD children as indicated by voxel-based cortical thickness and morphometry analysis.
作者信息
Kumar Uttam, Arya Amit, Agarwal Vivek
机构信息
Centre of Biomedical Research, Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Lucknow, India.
Department of Psychiatry, King George Medical University, Lucknow, India.
出版信息
Brain Dev. 2017 May;39(5):403-410. doi: 10.1016/j.braindev.2016.12.002. Epub 2017 Jan 2.
PURPOSE
Neuroimaging studies provide vital information related to the neurobiology of ADHD, but there still exists a wide gap in relevant information. The present study aimed to elucidate the neuroanatomical alteration in Attention deficit hyperactivity disorder (ADHD) children/adolescents.
METHODS
Voxel-based cortical thickness (VBCT) and voxel-based morphometry (VBM) was performed to examine neuroanatomic distinctions in 18 children/adolescents aged 7.5-13years diagnosed with DSM-IV TR as ADHD (non-medicated). They were compared with 18 healthy matched controls.
RESULTS
VBCT findings in ADHD children/adolescents revealed reduced cortical thickness in the left superior frontal, left orbito-frontal and left dorsal anterior cingulate cortex. VBM findings confirmed decreased gray matter volume in the left orbito frontal, left middle frontal/dorsolateral prefrontal, left middle temporal and left cerebellum in comparison to control group. A decrease in white matter volume was also observed in the left inferior frontal and left calcarine of ADHD children/adolescents.
CONCLUSION
Results reflect possible abnormal neuroanatomical development patterns in ADHD children.
目的
神经影像学研究为注意缺陷多动障碍（ADHD）的神经生物学提供了重要信息，但相关信息仍存在很大差距。本研究旨在阐明注意缺陷多动障碍儿童/青少年的神经解剖学改变。
方法
采用基于体素的皮质厚度（VBCT）和基于体素的形态学测量（VBM）方法，对18名年龄在7.5至13岁、被诊断为DSM-IV TR标准的ADHD（未用药）儿童/青少年的神经解剖差异进行研究。将他们与18名健康匹配对照进行比较。
结果
ADHD儿童/青少年的VBCT结果显示，左侧额上回、左侧眶额回和左侧背侧前扣带回皮质厚度降低。VBM结果证实，与对照组相比，左侧眶额回、左侧额中回/背外侧前额叶、左侧颞中回和左侧小脑灰质体积减少。ADHD儿童/青少年的左侧额下回和左侧距状裂也观察到白质体积减少。
结论
结果反映了ADHD儿童可能存在异常的神经解剖发育模式。
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