Stezin Albert, Lenka Abhishek, Jhunjhunwala Ketan, Saini Jitender, Pal Pramod K
Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India; Department of Clinical Neurosciences, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India.
Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India.
Parkinsonism Relat Disord. 2017 Mar;36:19-32. doi: 10.1016/j.parkreldis.2016.12.023. Epub 2016 Dec 26.
Progressive supranuclear palsy (PSP) is a progressive neurological disorder characterized by presence of supranuclear gaze palsy, early postural instability, parkinsonism and cognitive impairment. Advanced structural neuroimaging studies have demonstrated variable areas of grey and white matter involvement in PSP. Grey matter (GM) involvement is predominantly reported in the midbrain, subcortical structures such as thalamus and basal ganglia, and cerebellum. Most white matter (WM) tracts are also reported to be damaged in PSP. This review analyzes the published studies that have utilized advanced structural imaging techniques such as voxel based morphometry (VBM), diffusion tensor and diffusion weighted imaging (DTI, DWI), magnetic resonance volumetry (MRV), shape analysis, cortical thickness analysis and magnetic resonance morphometry in understanding the in vivo pathological changes in PSP and also discusses their clinical significance.
进行性核上性麻痹（PSP）是一种进行性神经疾病，其特征为存在核上性凝视麻痹、早期姿势不稳、帕金森症和认知障碍。先进的结构神经影像学研究已证明PSP患者的灰质和白质受累区域各不相同。灰质受累主要见于中脑、丘脑和基底神经节等皮质下结构以及小脑。多数白质束在PSP中也被报道存在损伤。本综述分析了已发表的利用诸如基于体素的形态学测量（VBM）、扩散张量和扩散加权成像（DTI、DWI）、磁共振容积测量（MRV）、形状分析、皮质厚度分析和磁共振形态测量等先进结构成像技术来理解PSP体内病理变化的研究，并讨论了它们的临床意义。
