Indermun Sunaina, Choonara Yahya E, Kumar Pradeep, du Toit Lisa C, Modi Girish, Luttge Regina, Govender Mershen, Pillay Viness
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Parktown 2193, South Africa.
Division of Neurosciences, Department of Neurology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.
J Pharm Sci. 2017 Apr;106(4):1111-1116. doi: 10.1016/j.xphs.2016.12.022. Epub 2017 Jan 3.
With a significant portion of the world suffering from chronic pain, the management and treatment of this condition still requires extensive research to successfully mobilize and functionalize its sufferers. This article details the in vitro and in vivo evaluation of a transdermal electro-modulated hydrogel-microneedle array (EMHM) device for the treatment of chronic pain. In vitro characterization of the electro-modulated hydrogel was undertaken before the determination of the in vivo release, histopathologic and pharmacokinetic profiles of the EMHM in a Sprague Dawley rat model. Pharmacokinetic modeling was conducted to establish a level A in vitro-in vivo correlation. Data analysis was carried out by segmenting the combined in vivo release profile into individualistic profiles before analysis.
世界上很大一部分人患有慢性疼痛，对这种疾病的管理和治疗仍需要进行广泛研究，以使患者成功活动并恢复功能。本文详细介绍了一种用于治疗慢性疼痛的经皮电调制水凝胶微针阵列（EMHM）装置的体外和体内评估。在确定EMHM在Sprague Dawley大鼠模型中的体内释放、组织病理学和药代动力学特征之前，先对电调制水凝胶进行了体外表征。进行药代动力学建模以建立A级体外-体内相关性。在分析之前，通过将体内联合释放曲线分割为单独的曲线来进行数据分析。
