Aixinjueluo Wei, Usui Tomohiko, Miyai Takashi, Toyono Tetsuya, Sakisaka Toshihiro, Yamagami Satoru
Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Division of Ophthalmology, Department of Visual Sciences, Nihon University, Chiyoda-ku, Japan.
Br J Ophthalmol. 2017 Sep;101(9):1244-1249. doi: 10.1136/bjophthalmol-2016-309775. Epub 2017 Jan 5.
BACKGROUND/AIMS: To evaluate the clinical results of accelerated transepithelial corneal cross-linking (CXL) in Japanese patients with progressive keratoconus (KCN).
Thirty eyes of 19 patients (16 male, 3 female patients) with progressive KCN were included. The mean age was 24.9±7.0 (range 16-38) years. All patients received ultraviolet A radiation for 3 min at an irradiance of 30 mW/cm. Patients were followed up on the first day, at 1 week and 2 weeks, and at 1 month, 3 months, 6 months and 12 months postoperatively. Clinical examinations included measures of uncorrected visual acuity, best corrected visual acuity (BCVA), average keratometry (AveK), maximum keratometry (Kmax), central corneal thickness, thinnest corneal thickness (TCT), endothelial cell density, intraocular pressure and non-mydriatic indirect fundus examination. Patients were asked to report any pain or discomfort at each visit.
There were no intraoperative or postoperative complications. All 30 eyes finished the follow-up. After 12 months, there was a significant decrease in Kmax (p<0.0001), AveK (p=0.003) and TCT (p=0.002), and a significant improvement in BCVA (p=0.001). There were no other significant changes. Pain or foreign-body sensation following CXL appeared in the first 2 days, but lasted no more than 1 week in all cases.
There were no complications associated with accelerated transepithelial corneal CXL, and the clinical outcomes were appraisable in a 12-month follow-up.
UMIN000009372.
背景/目的：评估加速经上皮角膜交联术（CXL）治疗日本进行性圆锥角膜（KCN）患者的临床效果。
纳入19例（16例男性，3例女性）进行性KCN患者的30只眼。平均年龄为24.9±7.0（范围16 - 38）岁。所有患者接受波长30 mW/cm的紫外线A照射3分钟。术后第1天、1周、2周、1个月、3个月、6个月和12个月对患者进行随访。临床检查包括测量未矫正视力、最佳矫正视力（BCVA）、平均角膜曲率（AveK）、最大角膜曲率（Kmax）、中央角膜厚度、最薄角膜厚度（TCT）、内皮细胞密度、眼压以及非散瞳间接眼底检查。每次随访时询问患者是否有疼痛或不适。
术中及术后均无并发症。所有30只眼均完成随访。12个月后，Kmax（p<0.0001）、AveK（p = 0.003）和TCT（p = 0.002）显著降低，BCVA显著改善（p = 0.001）。无其他显著变化。CXL术后疼痛或异物感出现在最初2天，但所有病例均不超过1周。
加速经上皮角膜CXL无相关并发症，12个月随访时临床结果可评估。
UMIN000009372。
