Acute myeloid leukemias with ring sideroblasts show a unique molecular signature straddling secondary acute myeloid leukemia and acute myeloid leukemia.
作者信息
Martin-Cabrera Pedro, Jeromin Sabine, Perglerovà Karolína, Haferlach Claudia, Kern Wolfgang, Haferlach Torsten
机构信息
MLL Munich Leukemia Laboratory, Germany.
MLL2 s.r.o., Prague, Czech Republic.
出版信息
Haematologica. 2017 Apr;102(4):e125-e128. doi: 10.3324/haematol.2016.156844. Epub 2017 Jan 5.
Abstract
摘要
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Acute myeloid leukemias with ring sideroblasts show a unique molecular signature straddling secondary acute myeloid leukemia and acute myeloid leukemia.伴有环形铁粒幼细胞的急性髓系白血病表现出一种独特的分子特征，跨越继发性急性髓系白血病和急性髓系白血病。
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本文引用的文献
1
Genomic Classification and Prognosis in Acute Myeloid Leukemia.急性髓系白血病的基因组分类与预后
N Engl J Med. 2016 Jun 9;374(23):2209-2221. doi: 10.1056/NEJMoa1516192.
2
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.2016 年版世界卫生组织髓系肿瘤和急性白血病分类。
Blood. 2016 May 19;127(20):2391-405. doi: 10.1182/blood-2016-03-643544. Epub 2016 Apr 11.
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Acute myeloid leukemia ontogeny is defined by distinct somatic mutations.急性髓系白血病的发生是由独特的体细胞突变所定义的。
Blood. 2015 Feb 26;125(9):1367-76. doi: 10.1182/blood-2014-11-610543. Epub 2014 Dec 30.
4
Refractory anemia with ring sideroblasts and marked thrombocytosis cases harbor mutations in SF3B1 or other spliceosome genes accompanied by JAK2V617F and ASXL1 mutations.伴有环形铁粒幼细胞和显著血小板增多症的难治性贫血病例存在SF3B1或其他剪接体基因的突变，并伴有JAK2V617F和ASXL1突变。
Haematologica. 2015 Apr;100(4):e125-7. doi: 10.3324/haematol.2014.119032. Epub 2014 Dec 19.
5
SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value.SF3B1 突变在环形铁幼粒细胞性难治性贫血伴原始细胞增多性骨髓增生异常综合征中较为常见，但不具有独立的预后价值。
Blood. 2012 Jan 12;119(2):569-72. doi: 10.1182/blood-2011-09-377994. Epub 2011 Nov 17.
6
Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.SF3B1 突变在骨髓增生异常综合征和骨髓增生异常/骨髓增殖性肿瘤中的临床意义。
Blood. 2011 Dec 8;118(24):6239-46. doi: 10.1182/blood-2011-09-377275. Epub 2011 Oct 12.
7
Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts.环形铁幼粒细胞性难治性贫血伴多系发育异常中的体细胞 SF3B1 突变。
N Engl J Med. 2011 Oct 13;365(15):1384-95. doi: 10.1056/NEJMoa1103283. Epub 2011 Sep 26.
8
Frequent pathway mutations of splicing machinery in myelodysplasia.骨髓增生异常综合征中剪接机制的频繁通路突变。
Nature. 2011 Sep 11;478(7367):64-9. doi: 10.1038/nature10496.
9
SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts.SF3B1是一种剪接因子，在伴有环形铁粒幼细胞的难治性贫血中经常发生突变。
Leukemia. 2012 Mar;26(3):542-5. doi: 10.1038/leu.2011.232. Epub 2011 Sep 2.
10
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.在英国医学研究理事会试验中治疗的 5876 例年轻成年患者中，对罕见重现染色体异常进行细胞遗传学分类的细化：确定其预后意义。
Blood. 2010 Jul 22;116(3):354-65. doi: 10.1182/blood-2009-11-254441. Epub 2010 Apr 12.
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