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单侧复发性前葡萄膜炎作为膀胱癌的首发症状

Unilateral Recurrent Anterior Uveitis as the Presenting Sign of Bladder Carcinoma.

作者信息

Şatırtav Günhal, Donbaloğlu Meryem, Oltulu Refik, Oltulu Pembe, Kerimoğlu Hürkan, Özkağnıcı Ahmet

机构信息

Necmettin Erbakan University Meram Faculty of Medicine, Department of Ophthalmology, Konya, Turkey.

Necmettin Erbakan University Meram Faculty of Medicine, Department of Pathology, Konya, Turkey.

出版信息

Turk J Ophthalmol. 2016 Aug;46(4):190-193. doi: 10.4274/tjo.92259. Epub 2016 Aug 15.

DOI:10.4274/tjo.92259
PMID:28058157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5200827/
Abstract

A 79-year-old male patient was followed for unilateral uveitis with 3 attacks in 10 months, despite initial improvement with steroid therapy. The patient had visual acuity (VA) of counting fingers in right eye, hypopyon and vitritis with no chorioretinal lesions. The left eye was normal. The patient was evaluated for intraocular foreign body, intraocular lymphoma and associated systemic disease and malignancy. Computed tomography of the abdomen showed a mass in the bladder. Biopsy confirmed bladder carcinoma. After resection of the mass, intraocular inflammation improved completely and no attack was noted in the follow-up. In his last examination, two years after the operation, VA was light perception; seclusio pupilla and mature cataracts were seen on biomicroscopy. There was no sign of vitritis on ocular ultrasonography. Evidence is discussed that suggests a link and potential etiology between refractory uveitis with hypopyon and bladder carcinoma. This is the first case of unilateral recurrent uveitis with hypopyon as the initial presenting sign of bladder carcinoma.

摘要

一名79岁男性患者,尽管最初使用类固醇治疗后病情有所改善,但在10个月内仍出现了3次单侧葡萄膜炎发作。患者右眼视力为指数,有前房积脓和玻璃体炎,无脉络膜视网膜病变。左眼正常。对该患者进行了眼内异物、眼内淋巴瘤及相关全身疾病和恶性肿瘤的评估。腹部计算机断层扫描显示膀胱有一个肿块。活检证实为膀胱癌。肿块切除后,眼内炎症完全改善,随访期间未再发作。在术后两年的最后一次检查中,视力为光感;生物显微镜检查可见瞳孔闭锁和成熟白内障。眼部超声检查未发现玻璃体炎迹象。本文讨论了支持前房积脓性难治性葡萄膜炎与膀胱癌之间存在关联及潜在病因的证据。这是首例以单侧复发性前房积脓性葡萄膜炎为膀胱癌首发表现的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e7c/5200827/fdf10e494cba/TJO-46-190-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e7c/5200827/b62857844689/TJO-46-190-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e7c/5200827/c937e160afa2/TJO-46-190-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e7c/5200827/725761b22f95/TJO-46-190-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e7c/5200827/83d3f49c675c/TJO-46-190-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e7c/5200827/56f0a8378bfc/TJO-46-190-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e7c/5200827/fdf10e494cba/TJO-46-190-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e7c/5200827/b62857844689/TJO-46-190-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e7c/5200827/c937e160afa2/TJO-46-190-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e7c/5200827/725761b22f95/TJO-46-190-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e7c/5200827/83d3f49c675c/TJO-46-190-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e7c/5200827/56f0a8378bfc/TJO-46-190-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e7c/5200827/fdf10e494cba/TJO-46-190-g6.jpg

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本文引用的文献

1
Bilateral uveitis with hypopyon as a presenting symptom of metastatic peritoneal carcinomatosis.
Eur J Ophthalmol. 2010 Sep-Oct;20(5):948-51. doi: 10.1177/112067211002000522.
2
Urothelial cell carcinoma of the bladder presenting as orbital metastasis.表现为眼眶转移的膀胱尿路上皮癌。
Arch Pathol Lab Med. 2008 Aug;132(8):1224. doi: 10.5858/2008-132-1224-UCCOTB.
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Paraneoplastic syndromes associated with visual loss.与视力丧失相关的副肿瘤综合征。
Curr Opin Ophthalmol. 2003 Dec;14(6):426-32. doi: 10.1097/00055735-200312000-00017.
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Uveitis in the elderly--is it easy to identify the masquerade?老年葡萄膜炎——伪装综合征容易识别吗?
Br J Ophthalmol. 1997 Oct;81(10):827-31. doi: 10.1136/bjo.81.10.827.
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Relapsing acute myeloid leukemia manifesting as hypopyon uveitis.表现为前房积脓性葡萄膜炎的复发性急性髓系白血病。
Am J Ophthalmol. 1995 Mar;119(3):361-4. doi: 10.1016/s0002-9394(14)71181-x.
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Carcinoma metastatic to the eye and orbit. I. A clinicopathologic study of 227 cases.眼及眼眶转移性癌。I. 227例临床病理研究。
Arch Ophthalmol. 1974 Oct;92(4):276-86. doi: 10.1001/archopht.1974.01010010286003.