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低剂量来那度胺治疗5q综合征患者后输血依赖性的显著反应:一例病例报告

Dramatic response in the dependency to transfusion after low doses of lenalidomide treatment in a 5q-syndrome patient: a case report.

作者信息

Dogu Mehmet Hilmi, Sari Ismail, Hacioglu Sibel, Keskin Ali

机构信息

Department of Hematology, Pamukkale University Faculty of Medicine, Denizli, Turkey.

出版信息

North Clin Istanb. 2015 Jan 24;1(3):191-193. doi: 10.14744/nci.2014.36036. eCollection 2014.

Abstract

5q-syndrome is a special subgroup of myelodysplastic syndrome in terms of follow-up and treatment. Lenalidomide is an immunomodulatory drug that is frequently used in the treatment of multiple myeloma. Some clinical studies have shown that lenalidomide treatment is effective in 5q syndrome and significantly decreases the transfusion dependency in these patients. In this paper, we would like to share a dramatic response of lowered transfusion dependency after treatment with low-dose lenalidomide in a patient who received myelodysplastic syndrome diagnosis and isolated 5q anomaly in our clinic.

摘要

就随访和治疗而言,5q综合征是骨髓增生异常综合征的一个特殊亚组。来那度胺是一种免疫调节药物,常用于治疗多发性骨髓瘤。一些临床研究表明,来那度胺治疗对5q综合征有效,并显著降低这些患者的输血依赖性。在本文中,我们想分享一例在我们诊所被诊断为骨髓增生异常综合征且存在孤立5q异常的患者,经低剂量来那度胺治疗后输血依赖性降低的显著反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c86/5175043/d9640e881474/NCI-1-191-g001.jpg

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