Dogu Mehmet Hilmi, Sari Ismail, Hacioglu Sibel, Keskin Ali
Department of Hematology, Pamukkale University Faculty of Medicine, Denizli, Turkey.
North Clin Istanb. 2015 Jan 24;1(3):191-193. doi: 10.14744/nci.2014.36036. eCollection 2014.
5q-syndrome is a special subgroup of myelodysplastic syndrome in terms of follow-up and treatment. Lenalidomide is an immunomodulatory drug that is frequently used in the treatment of multiple myeloma. Some clinical studies have shown that lenalidomide treatment is effective in 5q syndrome and significantly decreases the transfusion dependency in these patients. In this paper, we would like to share a dramatic response of lowered transfusion dependency after treatment with low-dose lenalidomide in a patient who received myelodysplastic syndrome diagnosis and isolated 5q anomaly in our clinic.
就随访和治疗而言,5q综合征是骨髓增生异常综合征的一个特殊亚组。来那度胺是一种免疫调节药物,常用于治疗多发性骨髓瘤。一些临床研究表明,来那度胺治疗对5q综合征有效,并显著降低这些患者的输血依赖性。在本文中,我们想分享一例在我们诊所被诊断为骨髓增生异常综合征且存在孤立5q异常的患者,经低剂量来那度胺治疗后输血依赖性降低的显著反应。