Lynchak O V, Prylutskyy Yu I, Rybalchenko V K, Kyzyma O A, Soloviov D, Kostjukov V V, Evstigneev M P, Ritter U, Scharff P
Taras Shevchenko National University of Kyiv, 64 Volodymyrska Str, 01601, Kyiv, Ukraine.
Joint Institute for Nuclear Research, Dubna, Moscow Region, Russia.
Nanoscale Res Lett. 2017 Dec;12(1):8. doi: 10.1186/s11671-016-1775-0. Epub 2017 Jan 5.
The antitumor activity of pristine C fullerene aqueous solution (CFAS) compared to 5-fluorouracil (5-FU) and pyrrole derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF-fenylamino)-1H-pyrrol-2.5-dione (MI-1) cytostatic drugs was investigated and analyzed in detail using the model of colorectal cancer induced by 1.2-dimethylhydrazine (DMH) in rats. The number, size, and location of the tumors were measured, and the pathology was examined. It was found that the number of tumors and total lesion area decreased significantly under the action of CFAS and MI-1. Because these drugs have different mechanisms of action, their simultaneous administration can potentially increase the effectiveness and significantly reduce the side effects of antitumor therapy.
在大鼠中，使用1,2-二甲基肼（DMH）诱导的结直肠癌模型，详细研究并分析了原始C富勒烯水溶液（CFAS）与5-氟尿嘧啶（5-FU）和吡咯衍生物1-(4-氯苄基)-3-氯-4-(CF-苯基氨基)-1H-吡咯-2,5-二酮（MI-1）等细胞抑制药物相比的抗肿瘤活性。测量了肿瘤的数量、大小和位置，并检查了病理情况。结果发现，在CFAS和MI-1的作用下，肿瘤数量和总病变面积显著减少。由于这些药物具有不同的作用机制，它们同时给药可能会提高疗效并显著降低抗肿瘤治疗的副作用。
