Wang Xiaoyu, Xu Linfeng, Lao Yuanzhi, Zhang Hongmei, Xu Hongxi
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, China.
Curr Protein Pept Sci. 2018 Feb 13;19(4):380-388. doi: 10.2174/1389203718666170106104211.
The epidermal growth factor receptor (EGFR) belongs to ErbB family of tyrosine kinases, which plays an important role in the regulation of cell proliferation, survival, differentiation, and metastasis. In addition, tumors develop resistance to EGFR inhibitors due to the presence or development of point mutations in the tyrosine kinase domain of the receptor. There is an urgent need to develop new anti-EGFR agents with strong therapeutic activities. As the majority of anticancer drugs are of natural origin, natural products are a valuable source for the identification and development of novel treatment options for cancer. To identify promising new anti-tumor agents that act on the EGFR, numerous studies have been carried out and some investigators found natural products that could effectively inhibit the EGFR. This review summarizes the latest developments related to anti- EGFR agents derived from natural compounds and traditional Chinese medicine (TCM).
表皮生长因子受体（EGFR）属于酪氨酸激酶的ErbB家族，在细胞增殖、存活、分化和转移的调节中起重要作用。此外，由于受体酪氨酸激酶结构域中存在点突变或其发生突变，肿瘤会对EGFR抑制剂产生耐药性。迫切需要开发具有强大治疗活性的新型抗EGFR药物。由于大多数抗癌药物都源自天然，天然产物是识别和开发癌症新治疗方案的宝贵来源。为了鉴定作用于EGFR的有前景的新型抗肿瘤药物，已经开展了大量研究，一些研究人员发现了能够有效抑制EGFR的天然产物。本综述总结了天然化合物和中药（TCM）衍生的抗EGFR药物的最新进展。
