Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA and Department of Dietetics and Nutrition, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Food Funct. 2017 Jan 25;8(1):372-380. doi: 10.1039/c6fo01216g.
Oxidative stress and inflammation are central to the development of a number of chronic diseases including cardiovascular disease and previous research suggests that blueberry consumption may attenuate these processes. The present study investigated the effects of blueberries on blood biomarkers of oxidative stress, inflammation, and antioxidant defense in postmenopausal women with pre- and stage 1-hypertension. In a randomized, parallel-arm, double-blind, placebo-controlled clinical trial, 40 pre- and stage 1-hypertensive postmenopausal women aged 45 to 65 years were randomly assigned to receive 22 g freeze-dried highbush blueberry powder per day (Blueberry) or 22 g placebo powder per day (Control) for 8 weeks. A blood biomarker of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine (8-OHdG), as well as blood biomarkers of oxidative stress, inflammation, and antioxidant defense were assessed at baseline, 4 and 8 weeks. 8-OHdG levels were significantly (P = 0.008) lower in Blueberry compared to Control at 4 weeks with a significant time-by-treatment interaction (P = 0.04). Levels were not different between groups at 8 weeks. Other biomarkers measured were not affected by blueberry consumption. Daily consumption of blueberries for 4 weeks, but not 8 weeks, attenuated a biomarker of oxidative DNA damage in pre- and stage 1-hypertensive postmenopausal women. Future clinical studies should directly evaluate the effects of blueberry consumption on oxidative stress, inflammation, and antioxidant defense at the cellular level and in the vasculature in this population.
氧化应激和炎症是许多慢性疾病（包括心血管疾病）发展的核心，先前的研究表明，蓝莓的摄入可能会减轻这些过程。本研究调查了蓝莓对患有前期和 1 期高血压的绝经后妇女血液氧化应激、炎症和抗氧化防御生物标志物的影响。在一项随机、平行臂、双盲、安慰剂对照的临床试验中，40 名年龄在 45 至 65 岁之间患有前期和 1 期高血压的绝经后妇女被随机分配每天服用 22 克冻干高丛蓝莓粉（蓝莓组）或 22 克安慰剂粉（对照组），持续 8 周。在基线、4 周和 8 周时，评估了血液氧化 DNA 损伤的生物标志物 8-羟基-2'-脱氧鸟苷（8-OHdG）以及氧化应激、炎症和抗氧化防御的血液生物标志物。与对照组相比，蓝莓组的 8-OHdG 水平在 4 周时显著降低（P = 0.008），且存在时间与治疗的交互作用（P = 0.04）。在 8 周时，两组之间的水平没有差异。其他测量的生物标志物不受蓝莓消耗的影响。每天食用蓝莓 4 周，但不是 8 周，可减轻前期和 1 期高血压绝经后妇女的氧化 DNA 损伤生物标志物。未来的临床研究应直接评估蓝莓摄入对该人群中氧化应激、炎症和抗氧化防御在细胞水平和血管中的影响。
