[果糖-1,6-二磷酸治疗慢性心力衰竭]

[Fructose-1,6-diphosphate in the treatment of chronic heart failure].

作者信息

Sun J P, Zhi G, Yang X S

出版信息

Zhonghua Nei Ke Za Zhi. 1989 May;28(5):274-6, 314.

Abstract

Fructose-1,6-diphosphate (FDP) was given to 30 patients with chronic heart failure (CHF) caused by various kinds of heart diseases with the purpose to evaluate the effects of FDP on CHF patients. Definite hemodynamic and clinical improvement has been found in this group. CO increased by 1.61 +/- 0.31 L/Min (35%) (P less than 0.01) PCWP decreased by 5.5 +/- 1.08 mmHg (31%); mean PAP decreased by 5.8 +/- 2.07 mmHg (P less than 0.05). EF increased by 6.9 +/- 1.5 (15.1%) as shown by echocardiography and the peak effect of the drug appeared at 2 hours after administration. The results showed that FDP is effective in the treatment of heart failure, especially in patients with dysfunction of other organs.

摘要

将1,6 - 二磷酸果糖（FDP）给予30例由各种心脏病引起的慢性心力衰竭（CHF）患者，目的是评估FDP对CHF患者的疗效。在该组患者中发现有明确的血流动力学和临床改善。心输出量（CO）增加了1.61±0.31升/分钟（35%）（P＜0.01），肺毛细血管楔压（PCWP）降低了5.5±1.08毫米汞柱（31%）；平均肺动脉压（mean PAP）降低了5.8±2.07毫米汞柱（P＜0.05）。超声心动图显示射血分数（EF）增加了6.9±1.5（15.1%），药物的峰值效应出现在给药后2小时。结果表明，FDP对心力衰竭治疗有效，尤其是对伴有其他器官功能障碍的患者。

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