Fraint Ellen, Miller Robin, Walter Andrew
*Department of Pediatrics †Division of Hematology/Oncology, Nemours/A.I duPont Hospital for Children at Thomas Jefferson University, Wilmington, DE.
J Pediatr Hematol Oncol. 2017 Mar;39(2):e71-e73. doi: 10.1097/MPH.0000000000000728.
Posterior reversible encephalopathy syndrome (PRES) and cerebral sinus thrombosis are 2 known complications of acute lymphoblastic leukemia and its treatment. We describe a patient with acute lymphoblastic leukemia whose course was complicated by both of these conditions. This case is novel both for the fact that PRES developed before the initiation of therapy and that PRES was followed shortly by the development of cerebral sinus thrombosis. Our patient's story raises questions about our current understanding of the pathophysiology of PRES, and it suggests that PRES may actually be a predisposing risk factor for cerebral sinus thrombosis.
后部可逆性脑病综合征（PRES）和脑静脉窦血栓形成是急性淋巴细胞白血病及其治疗已知的两种并发症。我们描述了一名急性淋巴细胞白血病患者，其病程因这两种情况而复杂化。该病例的新颖之处在于，PRES在治疗开始前就已出现，并且在PRES出现后不久就发生了脑静脉窦血栓形成。我们患者的情况引发了关于我们目前对PRES病理生理学理解的问题，并且表明PRES实际上可能是脑静脉窦血栓形成的一个易感危险因素。
