He L W
Beijing Cancer Institute.
Zhonghua Zhong Liu Za Zhi. 1989 Mar;11(2):121-3.
Estrogen and progesterone receptors (ER and PR) were detected in 400 women with primary breast cancer from 1979 to 1986. Cytosols showing saturable binding of 10 fmol/mg protein or more were taken as positive for ER and PR. The positive rate was 55.5% and 42.8%, respectively in this series. PR negative patients had higher risk of early recurrence than PR positive patients according to the highly significant difference between the two disease-free survival curves (P less than 0.01). The relative risk of recurrence in the PR negative group was 3.2 times higher than PR positive group (P less than 0.01). Simple ER positive or ER negative did not provide any relevant information for predicting the disease-free survival in this present series. Thirty months after mastectomy, 32.2% of the patients with PR negative tumors had recurrent disease as compared with the PR positive group (10.2%) (p less than 0.01). The recurrent rate was negatively correlated with tumor PR concentration. The prognostic value of PR status with respect to clinical stage, menopausal status and axillary node involvement is discussed. It is concluded that the PR content of breast cancer is an important predictor of prognosis and will help us to formulate treatment plan for the patients.
1979年至1986年期间，对400例原发性乳腺癌女性患者进行了雌激素和孕激素受体（ER和PR）检测。将每毫克蛋白质显示出10 fmol或更高的可饱和结合的胞质溶胶视为ER和PR阳性。该系列中ER和PR的阳性率分别为55.5%和42.8%。根据两条无病生存曲线之间的高度显著差异（P<0.01），PR阴性患者比PR阳性患者有更高的早期复发风险。PR阴性组的复发相对风险比PR阳性组高3.2倍（P<0.01）。单纯的ER阳性或阴性在本系列中未提供任何预测无病生存的相关信息。乳房切除术后30个月，PR阴性肿瘤患者的复发率为32.2%，而PR阳性组为10.2%（P<0.01）。复发率与肿瘤PR浓度呈负相关。讨论了PR状态对临床分期、绝经状态和腋窝淋巴结受累的预后价值。结论是，乳腺癌的PR含量是预后的重要预测指标，将有助于我们为患者制定治疗方案。
