Theodoropoulos Nicole, Whitson Bryan A, Martin Stanley I, Pouch Stephanie, Pope-Harman Amy
Division of Infectious Diseases & Immunology, Department of Medicine, UMass Memorial Medical Center, Worcester, MA, USA.
Division of Cardiac Surgery, Department of Surgery, The Ohio State University (OSU), Columbus, OH, USA.
Transpl Infect Dis. 2017 Apr;19(2). doi: 10.1111/tid.12659. Epub 2017 Feb 22.
Data are limited regarding the use of direct-acting antivirals for treatment of hepatitis C infection post lung transplant, especially in a donor-derived infection. We present a case of a lung transplant recipient with donor-derived hepatitis C that was successfully treated with a 12-week regimen of simeprevir and sofosbuvir. This case reiterates the importance of screening recipients of increased-risk donor organs for disease transmission and the value of early therapy.
关于直接作用抗病毒药物用于治疗肺移植后丙型肝炎感染的数据有限，尤其是在供体源性感染方面。我们报告了一例肺移植受者发生供体源性丙型肝炎的病例，该患者通过12周的simeprevir和sofosbuvir联合治疗方案成功治愈。该病例再次强调了对高风险供体器官受者进行疾病传播筛查的重要性以及早期治疗的价值。
