Lai B T
Beijing Lung Tumor Research Institute.
Zhonghua Zhong Liu Za Zhi. 1989 Mar;11(2):98-100.
Methylene blue can inhibit the growth of Ehrlich ascitic tumor, L1210 leukemia and P388 leukemia in mice. The average life span of the treated animals was obviously longer than that of the controls. Methylene blue was superior to 5-Fu in the treatment of L1210 leukemia of mice and two thirds of the mice with P388 leukemia were healthy and survived for more than 60 days after administrated different doses of methylene blue. When adriamycin was given simultaneously with methylene blue to mice, the acute toxic effect of adriamycin was decreased and the survival time prolonged. Methylene blue is a highly ionized and a rapidly eliminated drug which can combine well with tissues at higher concentration maintained for several hours and can easily pass through the blood-brain barrier.
亚甲蓝可抑制小鼠艾氏腹水瘤、L1210白血病和P388白血病的生长。经治疗的动物平均寿命明显长于对照组。在治疗小鼠L1210白血病方面，亚甲蓝优于5-氟尿嘧啶，给予不同剂量亚甲蓝后，三分之二的P388白血病小鼠健康存活超过60天。当亚甲蓝与阿霉素同时给予小鼠时，阿霉素的急性毒性作用降低，生存时间延长。亚甲蓝是一种高度离子化且迅速消除的药物，它能在较高浓度下与组织良好结合并维持数小时，且能轻易通过血脑屏障。
