通过合成细胞疗法设计实现高效制造和质量保证。
Achieving Efficient Manufacturing and Quality Assurance through Synthetic Cell Therapy Design.
机构信息
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, ON K1A 0K9, Canada; CCRM, Toronto, ON M5G 1L5, Canada.
出版信息
Cell Stem Cell. 2017 Jan 5;20(1):13-17. doi: 10.1016/j.stem.2016.12.003.
New methods to manipulate gene and cell state can be used to engineer cell functionality, simplify quality assessment, and enhance manufacturability. These strategies could help overcome unresolved cell therapy manufacturing challenges and complement frameworks to design quality into these complex cellular systems, ultimately increasing patient access to living therapeutics.
新的基因和细胞状态调控方法可用于工程细胞功能、简化质量评估和提高可制造性。这些策略有助于克服未解决的细胞治疗制造挑战，并补充设计这些复杂细胞系统质量的框架，最终增加患者获得活疗药物的机会。
Zotero 插件