Khangarot B S, Ray P K
Daphnia Project, Industrial Toxicology Research Centre, Lucknow, India.
Ecotoxicol Environ Saf. 1989 Oct;18(2):109-20. doi: 10.1016/0147-6513(89)90071-7.
Twenty-three metal ions were tested and ranked in terms of decrease in immobilization (EC50) of Daphnia magna Straus. The 48-hr EC50 values (mg/liter) of metal ions were Hg2+, 0.0052; Ag1+, 0.01; Cu2+, 0.093; Zn2+, 0.56; Co2+, 1.49; Cr6+, 1.79; Cd2+, 1.88; Be2+, 2.82; Pb2+, 3.61; As3+, 6.23; Fe2+, 7.20; Ni2+, 7.29; Mn2+, 8.28; Sn2+, 21.56; Ba2+, 32.00; Al3+, 59.60; W6+, 89.39; Sr2+, 94.00; K1+, 141.46; Mg2+, 343.56; Na1+, 420.60; and Sb3+, 423.45. The 48-hr EC50 values of 23 metal ions were transformed to their corresponding negative logarithms of molarity (as pM). Correlation coefficients (r) for more than 35 physiochemical properties of metals or metal ions and acute toxicity values (as pM) were examined by linear regression analysis. The negative logarithm of the solubility product constant of metal sulfide (pKsp), equilibrium constants of amino acids and of EDTA, nucleotide base, electronegativity, electrode potential, melting point, thermal properties of metals, and other physiochemical parameters were significantly correlated with toxicity for D. magna. The order of toxicity of metal ions has been presented and discussed. Correlation between toxicity and physiochemical properties of inorganic substances may be useful in predicting toxicity to various biologically important organisms.
对23种金属离子进行了测试，并根据大型溞（Daphnia magna Straus）活动抑制率的降低程度（半数有效浓度，EC50）进行了排序。金属离子的48小时EC50值（毫克/升）分别为：Hg2+，0.0052；Ag1+，0.01；Cu2+，0.093；Zn2+，0.56；Co2+，1.49；Cr6+，1.79；Cd2+，1.88；Be2+，2.82；Pb2+，3.61；As3+，6.23；Fe2+，7.20；Ni2+，7.29；Mn2+，8.28；Sn2+，21.56；Ba2+，32.00；Al3+，59.60；W6+，89.39；Sr2+，94.00；K1+，141.46；Mg2+，343.56；Na1+，420.60；Sb3+，423.45。将23种金属离子的48小时EC50值转换为其相应的摩尔浓度负对数（以pM表示）。通过线性回归分析检验了35种以上金属或金属离子的物理化学性质与急性毒性值（以pM表示）之间的相关系数（r）。金属硫化物的溶度积常数负对数（pKsp）、氨基酸和EDTA的平衡常数、核苷酸碱基、电负性、电极电位、熔点、金属的热性质以及其他物理化学参数与大型溞的毒性显著相关。文中给出并讨论了金属离子的毒性顺序。无机物毒性与物理化学性质之间的相关性可能有助于预测对各种具有生物学重要性的生物的毒性。
