Substrate-affinity relationship of succinate dehydrogenase in brain of albino rat during dieldrin toxicity.
作者信息
Reddy G R, Babu G R, Reddanna P, Chetty C S
机构信息
Department of Zoology, S.V. University, India.
出版信息
Ecotoxicol Environ Saf. 1989 Oct;18(2):141-4. doi: 10.1016/0147-6513(89)90074-2.
PMID:2806169
Abstract
Substrate kinetics of succinate dehydrogenase (EC 1.3.99.1) were studied in the brain of control and dieldrin-treated albino rats. Dieldrin inhibited the enzyme activity to various degrees and also altered the Michaelis-Menten constant (Km) of the enzyme. Activation energy values (delta E) were increased, suggesting decreased maximal velocity Vmax, and the high Km obtained for the enzyme also revealed decreased enzyme-substrate affinity and masking of active sites by dieldrin.
摘要
Zotero 插件