腹腔内顺铂和阿霉素作为不可切除卵巢癌的维持化疗：病例报告
Intraperitoneal cisplatin and doxorubicin as maintenance chemotherapy for unresectable ovarian cancer: a case report.
作者信息
Tempfer Clemens B, Hartmann Franziska, Hilal Ziad, Rezniczek Günther A
机构信息
Department of Obstetrics and Gynecology, Ruhr University Bochum, Bochum, Germany.
Department of Pathology, Ruhr University Bochum, Bochum, Germany.
出版信息
BMC Cancer. 2017 Jan 6;17(1):26. doi: 10.1186/s12885-016-3004-8.
BACKGROUND
Primary advanced, unresectable ovarian cancer (OC) is treated with palliative systemic chemotherapy. Intraperitoneal chemotherapy may be an alternative local maintenance therapy.
CASE PRESENTATION
A 75 year old woman with laparoscopically and histologically confirmed unresectable OC was treated with 13 cycles of intraperitoneal cisplatin 7.5 mg/m and doxorubicin 1.5 mg/m over 2 years using laparoscopic pressurized intraperitoneal aerosol chemotherapy (PIPAC). Objective tumor response (tumor regression on histology, stable disease on repeated video-laparoscopy and peritoneal carcinomatosis index) was noted. No Common Terminology Criteria for Adverse Events (CTCAE) > grade 3 were observed. EORTC QLQ-C30 quality of life measurements were stable throughout the therapy.
CONCLUSIONS
Repeated intraperitoneal chemotherapy with cisplatin and doxorubicin applied as PIPAC may be an effective maintenance treatment in women with primary advanced, unresectable OC.
背景
原发性晚期、无法切除的卵巢癌（OC）采用姑息性全身化疗进行治疗。腹腔内化疗可能是一种替代性的局部维持治疗方法。
病例报告
一名75岁女性，经腹腔镜检查及组织学确诊为无法切除的OC，在2年时间内接受了13个周期的腹腔镜加压腹腔内气溶胶化疗（PIPAC），使用顺铂7.5 mg/m²和阿霉素1.5 mg/m²进行腹腔内化疗。观察到客观肿瘤反应（组织学上肿瘤消退、重复视频腹腔镜检查时疾病稳定以及腹膜癌指数）。未观察到不良事件通用术语标准（CTCAE）>3级的情况。整个治疗过程中欧洲癌症研究与治疗组织QLQ-C30生活质量测量结果稳定。
结论
以PIPAC方式重复应用顺铂和阿霉素进行腹腔内化疗，对于原发性晚期、无法切除的OC女性患者可能是一种有效的维持治疗方法。
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