Langer P, Mess B, Ruzsás C, Gschwendtová K, Földes O, Bukovská M
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava.
Endocrinol Exp. 1989 Sep;23(3):167-83.
The results of 11 experiments in a total of 571 rats (initial body weight of 150-250 g) are reported and some findings differing from those by others are discussed. It was repeatedly found that the animals after bilateral or even unilateral superior cervical sympathetic gangliectomy (GX) did not gain body weight during the first week after surgery. Though they started to grow later, for several weeks their body weight remained significantly less than that of sham operated controls (SH). Though such phenomenon has not yet been described, it may well explain the increase of thyroid weight (as expressed per body weight) after gangliectomy alone or combined with antithyroid drug treatment or hypophysectomy as described by others. It was suggested that such changes may depend on general metabolic changes resulting in a striking inhibition of body weight gain rather than on some specific effect of GX on the thyroid. This view was supported by evaluating the data on absolute and relative thyroid weight from 4 experiments in a total of 265 animals. The level of thyroxine (T4) and thyrotropic hormone (TSG) was repeatedly found to be significantly decreased after GX for until about 72 h and 24 h after surgery, respectively, which was in agreement with the data reported by others. However, the onset of such decrease was repeatedly found to appear at 6 or 8 h after surgery (in one experiment even at 3 h after surgery) which is also contrasting to the onset of T4 decrease at 14 h after surgery as found by others who suggested a correlation of such thyroid depression with a depletion of noradrenaline from the thyroid and may be even from median eminence. In these experiments, however, a decrease of T4 level was found several hours before the depletion of noradrenaline from the thyroid which appeared at 12 h after surgery and remained at similar level until 40 days, while no remarkable changes of that were found in SH animals (with the excretion of slight increase after 24 h). Between about 4 and 40 days after surgery no significant changes in T4 and TSH levels after GX were found as compared with SH animals is in agreement with others.4+n one experiment the increase of T4 at 2 h after TRH injection, resulting apparently from the effect of endogenous TSH, was significantly inhibited in GX animals at 8 days after surgery, while in other experiments (at 8 and 40 days after surgery) no difference in T4 level increase was found in GX animals as compared with SH ones. In general, it may be suggested that superior cervical sympathetic gangliectomy may result in some temporary and perhaps transient changes in pituitary-thyroid function in rats.
报告了在总共571只大鼠（初始体重150 - 250克）身上进行的11项实验结果，并讨论了一些与他人不同的发现。反复发现，双侧甚至单侧颈上神经节切除术（GX）后的动物在手术后第一周体重没有增加。虽然它们后来开始生长，但在几周内其体重仍显著低于假手术对照组（SH）。尽管这种现象尚未被描述，但它很可能解释了单独进行神经节切除术或与抗甲状腺药物治疗或垂体切除术后甲状腺重量（按体重计算）的增加，正如其他人所描述的那样。有人认为，这种变化可能取决于导致体重增加显著抑制的一般代谢变化，而不是GX对甲状腺的某些特定作用。对总共265只动物的4项实验中关于绝对和相对甲状腺重量的数据进行评估，支持了这一观点。反复发现，GX后甲状腺素（T4）和促甲状腺激素（TSG）水平分别在手术后约72小时和24小时内显著下降，这与其他人报告的数据一致。然而，反复发现这种下降在手术后6或8小时出现（在一项实验中甚至在手术后3小时出现），这也与其他人发现的手术后14小时T4下降的起始时间形成对比，他们认为这种甲状腺功能减退与甲状腺甚至可能来自正中隆起的去甲肾上腺素耗竭有关。然而，在这些实验中，在甲状腺去甲肾上腺素在手术后12小时出现耗竭且直到40天保持在相似水平之前几个小时就发现了T4水平下降，而在SH动物中未发现明显变化（24小时后排泄略有增加）。与SH动物相比，在手术后约4至40天内，GX后T4和TSH水平未发现显著变化，这与其他人的结果一致。在一项实验中，手术后8天，GX动物中TRH注射后2小时T4的增加（显然是内源性TSH作用的结果）受到显著抑制，而在其他实验中（手术后8天和40天），与SH动物相比，GX动物中T4水平增加没有差异。一般来说，可以认为颈上神经节切除术可能导致大鼠垂体 - 甲状腺功能出现一些暂时的、也许是短暂的变化。
