焦虑症和惊恐障碍中的利钠肽

Natriuretic Peptides in Anxiety and Panic Disorder.

作者信息

Meyer T, Herrmann-Lingen C

机构信息

University of Göttingen Medical Centre, Göttingen, Germany; German Centre for Cardiovascular Research, University of Göttingen, Göttingen, Germany.

出版信息

Vitam Horm. 2017;103:131-145. doi: 10.1016/bs.vh.2016.08.002. Epub 2016 Oct 5.

DOI:10.1016/bs.vh.2016.08.002

PMID:28061968

Abstract

Natriuretic peptides exert pleiotropic effects on the cardiovascular system, including natriuresis, diuresis, vasodilation, and lusitropy, by signaling through membrane-bound guanylyl cyclases. In addition to their use as diagnostic and prognostic markers for heart failure, accumulating behavioral evidence suggests that these hormones also modulate anxiety symptoms and panic attacks. This review summarizes our current knowledge of the role of natriuretic peptides in animal and human anxiety and highlights some novel aspects from recent clinical studies on this topic.

摘要

利钠肽通过与膜结合的鸟苷酸环化酶信号传导，对心血管系统发挥多效性作用，包括利钠、利尿、血管舒张和舒张期功能改善。除了用作心力衰竭的诊断和预后标志物外，越来越多的行为学证据表明，这些激素还可调节焦虑症状和惊恐发作。本综述总结了我们目前对利钠肽在动物和人类焦虑中作用的认识，并强调了近期关于该主题的临床研究中的一些新方面。