雌激素受体对焦虑样行为的调节
Estrogen Receptors Modulation of Anxiety-Like Behavior.
作者信息
Borrow A P, Handa R J
机构信息
Colorado State University, Fort Collins, CO, United States.
Colorado State University, Fort Collins, CO, United States.
出版信息
Vitam Horm. 2017;103:27-52. doi: 10.1016/bs.vh.2016.08.004. Epub 2016 Oct 13.
Abstract
Estrogens exert profound effects on the expression of anxiety in humans and rodents; however, the directionality of these effects varies considerably within both clinical and preclinical literature. It is believed that discrepancies regarding the nature of estrogens' effects on anxiety are attributable to the differential effects of specific estrogen receptor (ER) subtypes. In this chapter we will discuss the relative impact on anxiety and anxiety-like behavior of each of the three main ERs: ERα, which has a generally anxiogenic effect, ERβ, which has a generally anxiolytic effect, and the G-protein-coupled ER known as GPR30, which has been found to both increase and decrease anxiety-like behavior. In addition, we will describe the known mechanisms by which these receptor subtypes exert their influence on emotional responses, focusing on the hypothalamic-pituitary-adrenal axis and the oxytocinergic and serotonergic systems. The impact of estrogens on the expression of anxiety is likely the result of their combined effects on all of these neurobiological systems.
摘要
雌激素对人类和啮齿动物的焦虑表达有着深远影响；然而，在临床和临床前文献中，这些影响的方向性差异很大。人们认为，雌激素对焦虑影响的性质存在差异，这归因于特定雌激素受体（ER）亚型的不同作用。在本章中，我们将讨论三种主要ER对焦虑及焦虑样行为的相对影响：ERα通常具有致焦虑作用，ERβ通常具有抗焦虑作用，以及被称为GPR30的G蛋白偶联雌激素受体，已发现其既能增加也能减少焦虑样行为。此外，我们将描述这些受体亚型对情绪反应产生影响的已知机制，重点关注下丘脑 - 垂体 - 肾上腺轴以及催产素能和血清素能系统。雌激素对焦虑表达的影响可能是它们对所有这些神经生物学系统综合作用的结果。
相似文献
1
Estrogen Receptors Modulation of Anxiety-Like Behavior.雌激素受体对焦虑样行为的调节
Vitam Horm. 2017;103:27-52. doi: 10.1016/bs.vh.2016.08.004. Epub 2016 Oct 13.
2
Estrogen, predominantly via estrogen receptor α, attenuates postpartum-induced anxiety- and depression-like behaviors in female rats.雌激素主要通过雌激素受体 α 减轻产后诱导的雌性大鼠焦虑和抑郁样行为。
Endocrinology. 2013 Oct;154(10):3807-16. doi: 10.1210/en.2012-2136. Epub 2013 Aug 2.
3
Activation of the G protein-coupled estrogen receptor, but not estrogen receptor α or β, rapidly enhances social learning.G蛋白偶联雌激素受体而非雌激素受体α或β的激活迅速增强社会学习能力。
Psychoneuroendocrinology. 2015 Aug;58:51-66. doi: 10.1016/j.psyneuen.2015.04.002. Epub 2015 Apr 13.
4
Localization of estrogen receptor ERα, ERβ and GPR30 on myenteric neurons of the gastrointestinal tract and their role in motility.雌激素受体ERα、ERβ和GPR30在胃肠道肌间神经元上的定位及其在运动中的作用。
Gen Comp Endocrinol. 2019 Feb 1;272:63-75. doi: 10.1016/j.ygcen.2018.11.016. Epub 2018 Nov 28.
5
The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice.氟西汀与环境丰富相结合，通过催产素能系统和 HPA 轴减少小鼠产后应激相关行为。
Sci Rep. 2021 Apr 19;11(1):8518. doi: 10.1038/s41598-021-87800-z.
6
Rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for estrogens (ERα, ERβ), oxytocin and serotonin (5-HT1A) in their brain.反复经历每日与幼崽短暂分离的大鼠母鼠，其母性行为增强、焦虑减轻，大脑中雌激素受体（ERα、ERβ）、催产素和5-羟色胺（5-HT1A）的水平也发生了变化。
Psychoneuroendocrinology. 2015 Feb;52:212-28. doi: 10.1016/j.psyneuen.2014.11.016. Epub 2014 Nov 24.
7
Estrogen receptors ERα and ERβ participation in hypothalamus-pituitary-adrenal axis activation by hemorrhagic stress.雌激素受体ERα和ERβ参与出血性应激引起的下丘脑-垂体-肾上腺轴激活。
Neuroscience. 2017 May 4;349:239-252. doi: 10.1016/j.neuroscience.2017.03.001. Epub 2017 Mar 6.
8
Neuroprotection in Parkinsonian-treated mice via estrogen receptor α activation requires G protein-coupled estrogen receptor 1.通过激活雌激素受体α对帕金森病治疗小鼠进行神经保护需要G蛋白偶联雌激素受体1。
Neuropharmacology. 2015 Aug;95:343-52. doi: 10.1016/j.neuropharm.2015.04.006. Epub 2015 Apr 17.
9
Molecular mechanisms mediating the neuroprotective role of the selective estrogen receptor modulator, bazedoxifene, in acute ischemic stroke: A comparative study with 17β-estradiol.介导选择性雌激素受体调节剂巴多昔芬在急性缺血性卒中中神经保护作用的分子机制：与17β-雌二醇的比较研究
J Steroid Biochem Mol Biol. 2017 Jul;171:296-304. doi: 10.1016/j.jsbmb.2017.05.001. Epub 2017 May 4.
10
Effects of estrogen receptor β or G protein-coupled receptor 30 activation on anxiety-like behaviors in relation to GABAergic transmission in stress-ovariectomized rats.雌激素受体β或G蛋白偶联受体30激活对应激去卵巢大鼠与γ-氨基丁酸能传递相关的焦虑样行为的影响。
Neurosci Lett. 2022 Oct 15;789:136885. doi: 10.1016/j.neulet.2022.136885. Epub 2022 Sep 21.
引用本文的文献
1
Estrogenic regulation of perineuronal nets in the mouse insular cortex and hippocampus.雌激素对小鼠岛叶皮质和海马体中神经元周围网络的调节作用。
Neuropharmacology. 2025 Nov 15;279:110641. doi: 10.1016/j.neuropharm.2025.110641. Epub 2025 Aug 16.
2
Sex-specific behavioral changes in middle-aged mice.中年小鼠的性别特异性行为变化。
Sci Rep. 2025 Jul 1;15(1):21992. doi: 10.1038/s41598-025-05001-4.
3
HSP Modulators for the Correction of Cognitive, Mnemonic, and Behavioral Disorders After Prenatal Hypoxia.用于纠正产前缺氧后认知、记忆和行为障碍的热休克蛋白调节剂
Biomedicines. 2025 Apr 17;13(4):982. doi: 10.3390/biomedicines13040982.
4
Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice.快速非基因组雌激素信号传导控制小鼠的饮酒行为。
Nat Commun. 2024 Dec 30;15(1):10725. doi: 10.1038/s41467-024-54737-6.
5
Hormone Regulation of Corticotropin-Releasing Factor Receptor 1 in the Female Mouse Brain.雌性小鼠大脑中促肾上腺皮质激素释放因子受体1的激素调节
Neuroendocrinology. 2024;114(12):1139-1157. doi: 10.1159/000542751. Epub 2024 Nov 25.
6
Accumbal Dopamine Responses Are Distinct between Female Rats with Active and Passive Coping Strategies.伏隔核多巴胺反应在具有主动和被动应对策略的雌性大鼠中存在差异。
Biomolecules. 2024 Oct 10;14(10):1280. doi: 10.3390/biom14101280.
7
A study of association between early menarche and anxiety in undergraduate students.一项关于大学生初潮与焦虑之间关联的研究。
F1000Res. 2024 Aug 9;13:807. doi: 10.12688/f1000research.149757.2. eCollection 2024.
8
Potential Differences in Psychedelic Actions Based on Biological Sex.基于生物学性别差异的迷幻药物作用的潜在差异。
Endocrinology. 2024 Jul 1;165(8). doi: 10.1210/endocr/bqae083.
9
Modeling Sex-Bias in Anxiety: Pros and Cons of a Larval Zebrafish Model.焦虑症中性别偏见的建模：斑马鱼幼体模型的利弊
Chronic Stress (Thousand Oaks). 2024 Jun 17;8:24705470241261781. doi: 10.1177/24705470241261781. eCollection 2024 Jan-Dec.
10
"Not feeling like myself" in perimenopause - what does it mean? Observations from the Women Living Better survey.围绝经期的“感觉不像自己”意味着什么？来自 Women Living Better 调查的观察结果。
Menopause. 2024 May 1;31(5):390-398. doi: 10.1097/GME.0000000000002339. Epub 2024 Mar 23.
本文引用的文献
1
Transmembrane helices in "classical" nuclear reproductive steroid receptors: a perspective.“经典”核生殖甾体受体中的跨膜螺旋：一种观点。
Nucl Recept Signal. 2015 Jul 21;13:e003. doi: 10.1621/nrs.13003. eCollection 2015.
2
Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS-Cognitive and Affective Study.激素疗法对近期绝经后女性认知和情绪的影响：随机对照KEEPS认知与情感研究的结果
PLoS Med. 2015 Jun 2;12(6):e1001833; discussion e1001833. doi: 10.1371/journal.pmed.1001833. eCollection 2015 Jun.
3
International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators.国际基础与临床药理学联合会。XCVII。G蛋白偶联雌激素受体及其药理学调节剂。
Pharmacol Rev. 2015 Jul;67(3):505-40. doi: 10.1124/pr.114.009712.
4
GPER1 (GPR30) knockout mice display reduced anxiety and altered stress response in a sex and paradigm dependent manner.GPER1（GPR30）基因敲除小鼠表现出焦虑减轻，且应激反应依性别和实验范式而异。
Horm Behav. 2014 Sep;66(4):628-36. doi: 10.1016/j.yhbeh.2014.09.001. Epub 2014 Sep 16.
5
Estrogenic mediation of serotonergic and neurotrophic systems: implications for female mood disorders.雌激素对血清素能和神经营养系统的调节作用：对女性情绪障碍的影响。
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:13-25. doi: 10.1016/j.pnpbp.2014.05.009. Epub 2014 May 24.
6
Oxytocin in the prelimbic medial prefrontal cortex reduces anxiety-like behavior in female and male rats.内侧前额叶皮质前边缘区的催产素可降低雌性和雄性大鼠的焦虑样行为。
Psychoneuroendocrinology. 2014 Jul;45:31-42. doi: 10.1016/j.psyneuen.2014.03.009. Epub 2014 Mar 29.
7
GPR30 activation decreases anxiety in the open field test but not in the elevated plus maze test in female mice.GPR30激活可降低雌性小鼠在旷场试验中的焦虑水平，但在高架十字迷宫试验中则不然。
Brain Behav. 2014 Jan;4(1):51-9. doi: 10.1002/brb3.197. Epub 2013 Nov 27.
8
Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats.雌激素受体β与催产素相互作用，调节成年雄性和雌性大鼠的焦虑样行为及神经内分泌应激反应性。
Physiol Behav. 2014 Apr 22;129:287-96. doi: 10.1016/j.physbeh.2014.03.004. Epub 2014 Mar 13.
9
Activation of the G-protein coupled receptor 30 (GPR30) has different effects on anxiety in male and female mice.G蛋白偶联受体30（GPR30）的激活对雄性和雌性小鼠的焦虑有不同影响。
Steroids. 2014 Mar;81:49-56. doi: 10.1016/j.steroids.2013.11.004. Epub 2013 Nov 14.
10
Reproductive experience alters neural and behavioural responses to acute oestrogen receptor α activation.生殖经历会改变对急性雌激素受体α激活的神经和行为反应。
J Neuroendocrinol. 2013 Dec;25(12):1280-1289. doi: 10.1111/jne.12113.
Zotero 插件