Fu Qiang, Wei Zigong, Xiao Pingping, Chen Yaosheng, Liu Xiaohong
School of Life Science, Foshan University, Guangdong 528231, PR China; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
Vet Microbiol. 2017 Jan;198:121-126. doi: 10.1016/j.vetmic.2016.12.030. Epub 2016 Dec 21.
Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is an important pathogen associated with a wide range of diseases in many mammalian species. CD44 is a transmembrane adhesion molecule involved in innate and adaptive immune responses. The aim of this study was to determine the protective role of CD44 during S. zooepidemicus infection. CD44-deficient mice exhibited reduced macrophage accumulation in the bronchoalveolar space and enhanced bacterial outgrowth and dissemination, which resulted in reduced mouse survival. An in vitro analysis revealed that CD44 can directly bind to S. zooepidemicus. Additionally, S. zooepidemicus interacted with macrophage-associated CD44, as reflected by the reduced uptake of S. zooepidemicus by CD44-deficient macrophages. These data suggest that CD44 contributes to effective antibacterial defense during S. zooepidemicus infection, thereby limiting the accompanying injury and death.
马链球菌兽疫亚种（兽疫链球菌）是一种重要的病原体，与许多哺乳动物物种的多种疾病相关。CD44是一种参与固有免疫和适应性免疫反应的跨膜黏附分子。本研究的目的是确定CD44在兽疫链球菌感染期间的保护作用。CD44缺陷小鼠在支气管肺泡空间中的巨噬细胞积累减少，细菌生长和扩散增强，导致小鼠存活率降低。体外分析表明，CD44可直接与兽疫链球菌结合。此外，兽疫链球菌与巨噬细胞相关的CD44相互作用，这表现为CD44缺陷巨噬细胞对兽疫链球菌的摄取减少。这些数据表明，CD44在兽疫链球菌感染期间有助于有效的抗菌防御，从而限制伴随的损伤和死亡。
