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利伐沙班可减少左心房和右下肺静脉内血栓数量,经食管超声心动图显示了这一点,但80层多层螺旋CT未显示。

Rivaroxaban lessens the number of thrombi in the left atrium and right lower pulmonary vein, as illustrated by transoesophageal echocardiography but not 80-MDCT.

作者信息

Takeuchi Hidekazu

机构信息

Ogachi Chuo Byoin, Akita, Japan.

出版信息

BMJ Case Rep. 2017 Jan 6;2017:bcr2016218036. doi: 10.1136/bcr-2016-218036.

DOI:10.1136/bcr-2016-218036
PMID:28062433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5293135/
Abstract

Stroke is a clinically important problem. A left atrial thrombus is known as a cause of ischaemic stroke. A pulmonary vein thrombus (PVT) is thought to be rare; however, PVT is common in elderly patients. Additionally, images of PVT with transoesophageal echocardiography (TEE) following treatment have not been well contrasted with that from either 64 or 80-slice multidetector CT (80-MDCT). The images of such changes depicted by TEE remain unknown. An 87-year-old man with hypertension was examined by 80-MDCT and TEE to check the cardiac thrombus. Although 80-MDCT did not depict the thrombus, TEE depicted the thrombus in the left atrium and right lower pulmonary vein (RLPV) clearly. After 6 months of rivaroxaban treatment, the thrombus in the RLPV decreased slightly and the thrombus in the left atrium became small and lucent, as estimated with TEE. Rivaroxaban decreased the size of the thrombus and changed the quality of the thrombus.

摘要

中风是一个具有临床重要性的问题。左心房血栓是缺血性中风的一个已知病因。肺静脉血栓(PVT)被认为较为罕见;然而,PVT在老年患者中很常见。此外,经食管超声心动图(TEE)检查治疗后PVT的图像与64排或80排多层螺旋CT(80-MDCT)的图像对比情况不佳。TEE所描绘的此类变化的图像仍不为人所知。一名患有高血压的87岁男性接受了80-MDCT和TEE检查以排查心脏血栓。尽管80-MDCT未显示血栓,但TEE清晰地显示了左心房和右下肺静脉(RLPV)中的血栓。利伐沙班治疗6个月后,经TEE评估,RLPV中的血栓略有减少,左心房中的血栓变小且变得透亮。利伐沙班减小了血栓的大小并改变了血栓的性质。

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本文引用的文献

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Nearly all left atrial thrombi may be extended from pulmonary vein thrombi.几乎所有左心房血栓可能都源自肺静脉血栓。
Int J Cardiol Heart Vasc. 2015 Feb 7;7:9. doi: 10.1016/j.ijcha.2015.01.013. eCollection 2015 Jun 1.
2
Left atrial thrombus resolution in atrial fibrillation or flutter: Results of a prospective study with rivaroxaban (X-TRA) and a retrospective observational registry providing baseline data (CLOT-AF).心房颤动或心房扑动患者左心房血栓溶解情况:利伐沙班前瞻性研究(X-TRA)及提供基线数据的回顾性观察登记研究(CLOT-AF)结果
Am Heart J. 2016 Aug;178:126-34. doi: 10.1016/j.ahj.2016.05.007. Epub 2016 May 17.
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Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study.22 个国家缺血性卒中和脑出血的危险因素研究(INTERSTROKE 研究):一项病例对照研究。
Lancet. 2010 Jul 10;376(9735):112-23. doi: 10.1016/S0140-6736(10)60834-3. Epub 2010 Jun 17.
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Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis.同型半胱氨酸与心血管疾病:一项荟萃分析得出的因果关系证据
BMJ. 2002 Nov 23;325(7374):1202. doi: 10.1136/bmj.325.7374.1202.