兔骨骼肌糖原素的氨基酸序列。
The amino acid sequence of rabbit skeletal muscle glycogenin.
作者信息
Campbell D G, Cohen P
机构信息
Department of Biochemistry, University of Dundee, Scotland, UK.
出版信息
Eur J Biochem. 1989 Oct 20;185(1):119-25. doi: 10.1111/j.1432-1033.1989.tb15090.x.
The amino acid sequence of glycogenin from rabbit skeletal muscle has been determined. The N-acetylated protein consists of 332 amino acids and has a molecular mass of 37278 Da. The novel tyrosyl-glucose linkage between glycogenin and glycogen [Smythe, C., Caudwell, F. B., Ferguson, M. & Cohen, P. (1988) EMBO J. 7, 2681-2686] is shown to occur at a single site, tyrosine-194. Although glycogenin is a UDP-Glc utilising glucosyltransferase that self-glucosylates [Pitcher, J., Smythe, C. & Cohen, P. (1988) Eur. J. Biochem. 176, 391-395], following addition by an unknown enzyme of the first glucose to tyrosine-194, it is not homologous to either human glycogen synthase or other UDP-Glc-requiring enzymes.
已确定兔骨骼肌中糖原素的氨基酸序列。N - 乙酰化蛋白由332个氨基酸组成，分子量为37278道尔顿。糖原素与糖原之间新的酪氨酰 - 葡萄糖连接 [斯迈思，C.，考德威尔，F. B.，弗格森，M. & 科恩，P.（1988年）《欧洲分子生物学组织杂志》7，2681 - 2686] 显示发生在单个位点，即酪氨酸 - 194。尽管糖原素是一种利用UDP - 葡萄糖的葡糖基转移酶，可进行自我葡糖基化 [皮彻，J.，斯迈思，C. & 科恩，P.（1988年）《欧洲生物化学杂志》176，391 - 395]，但在一种未知酶将第一个葡萄糖添加到酪氨酸 - 194之后，则它与人糖原合酶或其他需要UDP - 葡萄糖的酶均不同源。
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