Donet Jean A, Sornmayura Kay, Gulau Matthew, Schiff Eugene
Division of Gastroenterology, University of Miami Leonard Miller School of Medicine, Miami, FL, USA.
Division of Hepatology, Miller School of Medicine, University of Miami. Coral Gables, Florida, United States.
Rev Gastroenterol Peru. 2016 Oct-Dec;36(4):350-353.
Herbs are commonly used worldwide for the treatment of various diseases, constituting a multi-billion dollar market. Unfortunately, hepatotoxicity induced by herbs is also common. The true incidence and prevalence are not known. There is need for more strict regulations andexperimental and pre-clinical studies regarding its efficacy and safety. There is no gold standard for the diagnosis of herbs-induced liver injury (HILI) and it constitutes a diagnostic challenge for the clinician, whereestablishing causality could be cumbersome. Clinical presentation varies from asymptomatic cases with mildly abnormal liver tests to fulminant liver failure requiring liver transplantation. In this review, we will discuss the epidemiology, clinical manifestations, challenges and diagnostic approach of HILI and will also present some exemplary cases from the University of Miami, Division of Hepatology.
草药在全球范围内广泛用于治疗各种疾病，构成了一个价值数十亿美元的市场。不幸的是，草药引起的肝毒性也很常见。其真实发病率和流行率尚不清楚。需要对其疗效和安全性制定更严格的法规以及进行实验和临床前研究。目前尚无诊断草药性肝损伤（HILI）的金标准，这对临床医生来说是一项诊断挑战，确定因果关系可能很麻烦。临床表现从肝功能检查轻度异常的无症状病例到需要肝移植的暴发性肝衰竭不等。在本综述中，我们将讨论HILI的流行病学、临床表现、挑战和诊断方法，还将介绍迈阿密大学肝病科的一些典型病例。
