Christiansen Paul, Townsend Gareth, Knibb Graeme, Field Matt
Department of Psychological Sciences, University of Liverpool, Liverpool, L69 7ZA, UK.
UK Centre for Tobacco and Alcohol Studies (UKCTAS), Nottingham, UK.
Psychopharmacology (Berl). 2017 Mar;234(5):827-835. doi: 10.1007/s00213-016-4518-0. Epub 2017 Jan 7.
Acute 'priming' doses of alcohol reliably increase alcohol-seeking behaviour in social drinkers. However, the effects of the anticipated (rather than pharmacological) effects of alcohol, and their interaction with contextual alcohol cues, are not well understood.
This study aims to determine the extent to which an alcohol-placebo drink increases craving, subjective intoxication and beer consumption, while conjointly investigating the impact of contextual alcohol cues.
On a within-subject basis, 64 undergraduate social drinkers consumed both a placebo (which they believed to contain alcohol) and a control drink (which they knew did not contain alcohol) in different sessions. Participants completed the study procedures in a bar laboratory designed to look like a 'pub' or a standard psychology lab containing no alcohol-related cues. Craving (Desires for Alcohol Questionnaire) and subjective intoxication were measured pre- and post-drink, and a bogus taste test to measure ad-lib alcohol consumption was completed at the end of each session.
Compared to the control drink, placebo significantly increased craving, ad-lib consumption and subjective intoxication, regardless of environmental context.
Increased craving and ad-lib alcohol consumption after consuming a priming dose of alcohol is at least partly attributable to the anticipated rather than the pharmacological effects of the priming dose.
急性“启动”剂量的酒精能可靠地增加社交饮酒者对酒精的寻觅行为。然而,酒精预期(而非药理)效应及其与情境性酒精线索的相互作用尚未得到充分理解。
本研究旨在确定酒精安慰剂饮料在多大程度上会增加渴望、主观醉酒感和啤酒饮用量,同时联合调查情境性酒精线索的影响。
在受试者自身对照的基础上,64名本科社交饮酒者在不同时段分别饮用了一种安慰剂(他们认为含有酒精)和一种对照饮料(他们知道不含酒精)。参与者在一个设计成“酒吧”模样的实验室或一个不含任何酒精相关线索的标准心理学实验室中完成研究程序。在饮酒前后测量渴望程度(酒精渴望问卷)和主观醉酒感,并且在每个时段结束时完成一项用于测量随意酒精饮用量的假口味测试。
与对照饮料相比,无论环境背景如何,安慰剂均显著增加了渴望程度、随意饮用量和主观醉酒感。
饮用启动剂量酒精后渴望程度增加和随意酒精饮用量增加至少部分归因于启动剂量的预期效应而非药理效应。