微小RNA在肝细胞代谢及乙型肝炎病毒复制中的作用
The role of microRNAs in hepatocyte metabolism and hepatitis B virus replication.
作者信息
Deng Wanyu, Lu Mengji
机构信息
College of Life Science, Shangrao Normal University, Shangrao, 334001, China.
Institute of Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, 45147, Germany.
出版信息
Virol Sin. 2016 Dec;31(6):472-479. doi: 10.1007/s12250-016-3924-0. Epub 2016 Dec 28.
Abstract
Though efficient vaccines against hepatitis B virus (HBV) and antiviral therapies are available, chronic HBV infection is still a global health problem. The process of HBV infection and HBV life cycle are extensively studied in last decades, however, the mechanisms of HBV-induced alterations of host cell metabolisms and host factors involved in modulating of viral replication are not fully understood. Thus, it is an important issue to examine these specific HBV-host interactions for development of novel strategies for antiviral therapies. Recently, microRNAs (miRNAs), a class of post-transcriptional regulatory small RNA, seem to be the relevant fine tuning factors of various cellular activities and pathways, including cell growth, metabolism, and viral replication. In this review, we summarize the up to date knowledge concerning the virus-host interactions and emphasizing on the role of miRNAs in regulation of HBV replication and host cell metabolism.
摘要
尽管有针对乙型肝炎病毒（HBV）的高效疫苗和抗病毒疗法，但慢性HBV感染仍然是一个全球性的健康问题。在过去几十年中，人们对HBV感染过程和HBV生命周期进行了广泛研究，然而，HBV诱导宿主细胞代谢改变的机制以及参与调节病毒复制的宿主因子尚未完全了解。因此，研究这些特定的HBV-宿主相互作用对于开发新的抗病毒治疗策略是一个重要问题。最近，微小RNA（miRNA），一类转录后调控的小RNA，似乎是各种细胞活动和途径（包括细胞生长、代谢和病毒复制）的相关微调因子。在这篇综述中，我们总结了关于病毒-宿主相互作用的最新知识，并着重阐述了miRNA在调节HBV复制和宿主细胞代谢中的作用。
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