Ghosh Sudipta, Dosaev Tasbulat, Prakash Jai, Livshits Gregory
Department of Anthropology, North-Eastern Hill University, Shillong, Meghalaya, 793022, India.
Department of Anatomy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Am J Phys Anthropol. 2017 Apr;162(4):701-714. doi: 10.1002/ajpa.23161. Epub 2017 Jan 7.
The major aim of this study was to conduct comparative quantitative-genetic analysis of the body composition (BCP) and somatotype (STP) variation, as well as their correlations with blood pressure (BP) in two ethnically, culturally and geographically different populations: Santhal, indigenous ethnic group from India and Chuvash, indigenous population from Russia.
Correspondently two pedigree-based samples were collected from 1,262 Santhal and1,558 Chuvash individuals, respectively. At the first stage of the study, descriptive statistics and a series of univariate regression analyses were calculated. Finally, multiple and multivariate regression (MMR) analyses, with BP measurements as dependent variables and age, sex, BCP and STP as independent variables were carried out in each sample separately. The significant and independent covariates of BP were identified and used for re-examination in pedigree-based variance decomposition analysis.
Despite clear and significant differences between the populations in BCP/STP, both Santhal and Chuvash were found to be predominantly mesomorphic irrespective of their sex. According to MMR analyses variation of BP significantly depended on age and mesomorphic component in both samples, and in addition on sex, ectomorphy and fat mass index in Santhal and on fat free mass index in Chuvash samples, respectively. Additive genetic component contributes to a substantial proportion of blood pressure and body composition variance. Variance component analysis in addition to above mentioned results suggests that additive genetic factors influence BP and BCP/STP associations significantly.
本研究的主要目的是对两个在种族、文化和地理上不同的人群——来自印度的原住民桑塔尔族和来自俄罗斯的楚瓦什族——的身体成分（BCP）和体型（STP）变异，以及它们与血压（BP）的相关性进行比较定量遗传分析。
相应地，分别从1262名桑塔尔族和1558名楚瓦什族个体中收集了两个基于家系的样本。在研究的第一阶段，计算了描述性统计量和一系列单变量回归分析。最后，在每个样本中分别进行了以血压测量值为因变量、年龄、性别、BCP和STP为自变量的多元回归（MMR）分析。确定了血压的显著且独立的协变量，并将其用于基于家系的方差分解分析中的重新检验。
尽管两个群体在BCP/STP方面存在明显且显著的差异，但无论性别如何，桑塔尔族和楚瓦什族都主要为匀称体型。根据MMR分析，两个样本中血压的变异均显著取决于年龄和匀称体型成分，此外，在桑塔尔族样本中还取决于性别、瘦体型和脂肪质量指数，在楚瓦什族样本中则取决于去脂体重指数。加性遗传成分在血压和身体成分变异中占很大比例。除上述结果外，方差成分分析表明加性遗传因素对血压与BCP/STP的关联有显著影响。
