Bergqvist L, Strand S E
Department of Radiation Physics, University of Lund, Sweden.
Eur J Nucl Med. 1989;15(10):641-5. doi: 10.1007/BF00251676.
In many nuclear medicine applications a well defined particle size and stability of administered colloids is of great importance. A fast and reliable sizing technique for routine quality control is therefore essential. This paper evaluates autocorrelation spectroscopy with an instrument capable of analysing several peaks simultaneously. A total of nine 99mTc-labelled colloids and one 99Y-labelled colloid were studied. The autocorrelation spectroscopy measurements were compared with the standard sizing technique of microfiltration. A good agreement between the sizing techniques was found for most of the colloids. The reproducibility of successive measurements was within +/- 12% and +/- 40% when using unimodal analysis and SDP analysis, respectively. Autocorrelation spectroscopy was found to be well suited for particle sizing and stability tests of radiolabelled colloids.
在许多核医学应用中，给药胶体的明确粒径和稳定性至关重要。因此，一种用于常规质量控制的快速可靠的粒径测定技术必不可少。本文使用一种能够同时分析多个峰的仪器对自相关光谱法进行了评估。共研究了九种99mTc标记的胶体和一种99Y标记的胶体。将自相关光谱法测量结果与微滤标准粒径测定技术进行了比较。发现大多数胶体的粒径测定技术之间具有良好的一致性。分别使用单峰分析和SDP分析时，连续测量的重现性分别在+/- 12%和+/- 40%以内。发现自相关光谱法非常适合放射性标记胶体的粒径测定和稳定性测试。
