Khan Serajul I, Hübner Patrick P, Brichta Alan M, Smith Doug W, Migliaccio Americo A
Balance and Vision Laboratory, Neuroscience Research Australia, Sydney, New South Wales, Australia; University of New South Wales, Sydney, New South Wales, Australia.
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia.
Neurobiol Aging. 2017 Mar;51:122-131. doi: 10.1016/j.neurobiolaging.2016.12.007. Epub 2016 Dec 18.
Prevailing evidence indicates a relatively late life decline in human vestibulo-ocular reflex (VOR) function. Although mice are commonly used in mechanistic studies of vestibular function, it remains unclear whether aging produces a corresponding decline in VOR function in mice. We sought to determine how the baseline VOR and its short-term adaptation were affected by aging. We tested 8 young (3-month old) and 8 aged (30-month old-equivalent to a ∼80-year old human) C57BL/6 mice. We measured their VOR response to whole-body static tilts and during 0.1-10 Hz whole-body sinusoidal and transient rotations before and after VOR adaptation training. Our data revealed minimal differences in static counter-tilt response between young and aged mice, but a significant deficit in baseline VOR gain in aged mice during transient rotations. Moreover, aged mice had a significant decrease in short-term VOR adaptation, particularly for training that sought to decrease the VOR response.
现有证据表明，人类前庭眼反射（VOR）功能在生命后期出现相对衰退。尽管小鼠常用于前庭功能的机制研究，但衰老是否会导致小鼠VOR功能出现相应衰退仍不清楚。我们试图确定衰老如何影响基线VOR及其短期适应性。我们测试了8只年轻（3个月大）和8只老年（相当于30个月大——约为80岁人类）的C57BL/6小鼠。我们测量了它们在VOR适应性训练前后对全身静态倾斜以及0.1 - 10Hz全身正弦和瞬态旋转的VOR反应。我们的数据显示，年轻和老年小鼠在静态反向倾斜反应上差异极小，但老年小鼠在瞬态旋转期间基线VOR增益存在显著缺陷。此外，老年小鼠的VOR短期适应性显著下降，特别是在旨在降低VOR反应的训练中。
