Martino Diego J, Valerio Marina P, Szmulewicz Alejandro G, Strejilevich Sergio A
Bipolar Disorder Program, Institute of Neurosciences, Favaloro University, Buenos Aires, Argentina; National Council of Scientific and Technical Research (CONICET), Argentina; Institute of Cognitive and Translational Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
National Council of Scientific and Technical Research (CONICET), Argentina; Psychiatric Emergencies Hospital Torcuato de Alvear, Buenos Aires, Argentina.
J Affect Disord. 2017 Mar 1;210:226-229. doi: 10.1016/j.jad.2016.12.053. Epub 2017 Jan 2.
The aim of this study was to assess if premorbid IQ moderates the association between measures of clinical severity and neurocognitive or psychosocial functioning in euthymic patients with bipolar disorder.
One hundred and nineteen outpatients and forty healthy controls were included. The length of illness, number of previous hypo/manic and depressive episodes, episode density, and history of psychosis assessed clinical severity. Performances in verbal memory, attention, and executive functions, as well as level of psychosocial functioning were used as outcomes.
The negative relationship between number of hypo/manic episodes and performance in executive functions decreased as a function of higher values of premorbid IQ. No other influences of premorbid IQ were found in the association between clinical severity measures and neurocognitive and psychosocial functioning.
Premorbid IQ might moderate the relationship between the number of hypo/manic episodes and executive functioning in bipolar disorder. Possible interpretations of this finding are discussed.
本研究旨在评估病前智商是否会调节双相情感障碍缓解期患者临床严重程度指标与神经认知或社会心理功能之间的关联。
纳入119名门诊患者和40名健康对照。通过患病时长、既往轻躁狂和抑郁发作次数、发作密度以及精神病病史来评估临床严重程度。将言语记忆、注意力和执行功能的表现以及社会心理功能水平作为研究结果。
随着病前智商值升高，轻躁狂发作次数与执行功能表现之间的负相关关系减弱。在临床严重程度指标与神经认知和社会心理功能的关联中，未发现病前智商的其他影响。
病前智商可能会调节双相情感障碍中轻躁狂发作次数与执行功能之间的关系。本文讨论了这一发现的可能解释。
