Kahn D, Hickman R, Dreyer C, Temple Camp C
Department of Surgery, University of Cape Town, South Africa.
Eur Surg Res. 1989;21(3-4):156-61. doi: 10.1159/000129018.
It has recently been suggested that the use of calcium channel-blocking agents may improve the results of renal transplantation either by enhancing the immunosuppressive effects of ciclosporin, or by improving posttransplant acute renal failure. In the present study, unlike others, verapamil was administered to the animals for 10 days posttransplant, alone or in conjunction with ciclosporin and/or solumedrol. In the group in which all three agents were given together, there were minimal changes in plasma urea or creatinine for the 10 days after transplantation. However, survival and the histological appearances of the kidneys at autopsy showed no improvement as compared with those in animals treated with cicloporin and steroids. There is thus no evidence from this study to suggest that verapamil could advantageously be added to a clinical immunosuppressive regime.
最近有人提出，使用钙通道阻滞剂可能会改善肾移植的结果，其途径要么是增强环孢素的免疫抑制作用，要么是改善移植后急性肾衰竭。在本研究中，与其他研究不同的是，在移植后10天给动物单独或联合环孢素和/或甲泼尼龙使用维拉帕米。在三种药物一起使用的组中，移植后10天血浆尿素或肌酐变化极小。然而，与接受环孢素和类固醇治疗的动物相比，尸检时的存活率和肾脏组织学表现并未改善。因此，这项研究没有证据表明维拉帕米可以有益地添加到临床免疫抑制方案中。
