Iso Y, Kitano S, Iwanaga T, Hashizume M, Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Eur Surg Res. 1989;21(3-4):175-83. doi: 10.1159/000129021.
We examined the pulmonary hemodynamics and morphology after injection of a sclerosing solution of 5% ethanolamine oleate (EO) into 24 normal dogs. EO of 0.5 ml/kg (n = 5), 1.0 ml/kg (n = 6), and 3.0 ml/kg (n = 7) was injected through the jugular vein into the right atrium for pathological examination and gravimetric study of the lung, while monitoring the pulmonary hemodynamics for 12 h. Normal saline of 3.0 ml/kg was injected into the remaining 6 control dogs, using the same method. Cardiac output significantly decreased immediately after injection of the sclerosant in all dogs given 0.5 ml/kg, 1.0 ml/kg and 3.0 ml/kg injections of EO; however, there was a tendency toward recovery from 6 h after injection in dogs given 0.5 ml/kg and from 9 h in dogs given 1.0 ml/kg. Pulmonary hypertension just after injection and hypoxia at 9-12 h occurred only when 3.0 ml/kg was injected. Irreversible pulmonary hemorrhage was present in the excised lungs in 4 of 7 dogs given 3.0 ml/kg, while there were no significant lesions in the other dogs. The lung water content in cases of 1.0 and 3.0 ml/kg injections was significantly higher than that in the controls, while there was no significant difference between those given 0.5 ml/kg and of the controls. The findings obtained in this study suggest that EO less than 0.5 ml/kg used for sclerosing esophageal varices seems to have little untoward influence on pulmonary hemodynamics and morphology.
我们对24只正常犬注射5%油酸乙醇胺（EO）硬化溶液后进行了肺血流动力学和形态学检查。将0.5 ml/kg（n = 5）、1.0 ml/kg（n = 6）和3.0 ml/kg（n = 7）的EO经颈静脉注入右心房，以进行肺的病理检查和重量研究，同时监测12小时的肺血流动力学。对其余6只对照犬采用相同方法注入3.0 ml/kg的生理盐水。在所有接受0.5 ml/kg、1.0 ml/kg和3.0 ml/kg EO注射的犬中，注射硬化剂后心输出量立即显著下降；然而，接受0.5 ml/kg注射的犬在注射后6小时有恢复趋势，接受1.0 ml/kg注射的犬在9小时有恢复趋势。仅在注射3.0 ml/kg时，注射后即刻出现肺动脉高压，9 - 12小时出现低氧血症。接受3.0 ml/kg注射的7只犬中有4只切除的肺出现不可逆性肺出血，而其他犬无明显病变。1.0 ml/kg和3.0 ml/kg注射组的肺含水量显著高于对照组，而0.5 ml/kg注射组与对照组之间无显著差异。本研究结果表明，用于硬化食管静脉曲张的EO剂量小于0.5 ml/kg似乎对肺血流动力学和形态学几乎没有不良影响。
