Matute-Blanch Clara, Río Jordi, Villar Luisa M, Midaglia Luciana, Malhotra Sunny, Álvarez-Cermeño José C, Vidal-Jordana Angela, Montalban Xavier, Comabella Manuel
Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
J Neuroimmunol. 2017 Feb 15;303:62-65. doi: 10.1016/j.jneuroim.2016.12.006. Epub 2016 Dec 18.
Chitinase 3-like 1 (CHI3L1) plays a prognostic role in patients with multiple sclerosis (MS). Here, we investigated a potential association between CHI3L1 and the response to interferon-beta (IFNβ) and glatiramer acetate (GA). Serum CHI3L1 levels were measured by ELISA in 117 relapsing-remitting MS (RRMS) patients, 76 IFNβ-treated and 41 GA-treated patients. CHI3L1 levels were increased by GA (p=0.014) but unchanged by IFNβ (p=0.830). CHI3L1 was associated with IFNβ response and levels were higher in non-responder group (p=0.020), while GA showed no responder effect (p=0.943). These results suggest a role for CHI3L1 as response biomarker to IFNβ in RRMS patients.
几丁质酶3样蛋白1（CHI3L1）在多发性硬化症（MS）患者中具有预后作用。在此，我们研究了CHI3L1与干扰素-β（IFNβ）和醋酸格拉替雷（GA）反应之间的潜在关联。通过酶联免疫吸附测定法（ELISA）测量了117例复发缓解型MS（RRMS）患者、76例接受IFNβ治疗的患者和41例接受GA治疗的患者的血清CHI3L1水平。GA可使CHI3L1水平升高（p = 0.014），而IFNβ对其无影响（p = 0.830）。CHI3L1与IFNβ反应相关，无反应组的CHI3L1水平更高（p = 0.020），而GA未显示出反应差异（p = 0.943）。这些结果表明CHI3L1在RRMS患者中作为IFNβ反应生物标志物的作用。
